Manjinder S. Cheema

TL;DR: It is shown that most promoters in mouse sperm are flanked by well-positioned nucleosomes marked by active histone modifications, suggesting that sperm carry a rich source of regulatory information, encoded in part by its three-dimensional folding specified by CTCF and cohesin.

TL;DR: This study shows that the N-terminal domains of MeCP2-E1 and E2 modulate the ability of the methyl-binding domain (MBD) to interact with DNA as well as influencing the turn-over rates, binding dynamics, response to neuronal depolarization, and circadian oscillations of the two isoforms.

TL;DR: It is found that modulating H4G expression affects rRNA expression levels, protein synthesis rates and cell-cycle progression, and the data suggest that H 4G expression alters nucleolar chromatin in a way that enhances rDNA transcription in breast cancer tissues.

TL;DR: The results presented in this work help configure a new evolutionary scenario in which histone variants, rather than modern “deviants” of canonical histones, would constitute ancient components of eukaryotic chromatin.

TL;DR: Monitoring two types of epigenetic mechanisms, namely histone modifications and DNA methylation, during a 7‐week‐long experiment in which staghorn coral fragments were exposed to nutrient stress (nitrogen, nitrogen + phosphorus) in the presence of thermal stress provides new insights into the role of epigenetics during coral responses to global change.