Wenli Zhang

TL;DR: Results presented here suggest that in human respiratory epithelial cells oxidative stress generated by DE(as) increases the susceptibility to influenza infection and that exposure to DE increases the ability of the virus to attach to and enter respiratory epithel cells.

TL;DR: Exposure to Zn2+ ions causes PTEN degradation and loss of function, which is mediated by an ubiquitin-associated proteolytic process in the airway epithelium.

TL;DR: The results demonstrate that treatment with H2O2 increased IKK activity, phosphorylation, and ubiquitination of I κ B α in NHBE cells, but there was no significant proteolytic degradation of Iδ B α, nuclear translocation of p65, or NF- δ B DNA binding activity in cells treated with H 2O2.

TL;DR: It is demonstrated that selenium deficiency has a significant impact on the morphology and influenza-induced host defense responses in human airway epithelial cells.

TL;DR: It is demonstrated that infection with influenza results in the reduced expression of transcription factor IRF7 in NECs from smokers, and that these effects may be mediated by an epigenetic modification of theIRF7 gene, thus providing a potential mechanism rendering smokers more susceptible to respiratory virus infections.