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Wenyong Xiong
Researcher at Chinese Academy of Sciences
Publications - 42
Citations - 1225
Wenyong Xiong is an academic researcher from Chinese Academy of Sciences. The author has contributed to research in topics: Adipogenesis & Glucose transporter. The author has an hindex of 17, co-authored 38 publications receiving 1033 citations. Previous affiliations of Wenyong Xiong include University of Southern California & Yunnan University.
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HIV-1 Protease Inhibitors Nelfinavir and Atazanavir Induce Malignant Glioma Death by Triggering Endoplasmic Reticulum Stress
TL;DR: The results support a model whereby PIs cause tumor cell death via triggering of the ESR, inhibition of proteasome activity, and subsequent accumulation of misfolded proteins.
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Calcium-activated endoplasmic reticulum stress as a major component of tumor cell death induced by 2,5-dimethyl-celecoxib, a non-coxib analogue of celecoxib.
Peter Pyrko,Adel Kardosh,Yen Ting Liu,Nathaniel Soriano,Wenyong Xiong,Robert H. Chow,Jasim Uddin,Nicos A. Petasis,Austin K. Mircheff,Robert A. Farley,Stan G. Louie,Thomas C. Chen,Axel H. Schönthal +12 more
TL;DR: DMC increases intracellular free calcium levels and potently triggers the ESR in various tumor cell lines, as indicated by transient inhibition of protein synthesis, activation of ER stress–associated proteins GRP78/BiP, CHOP/GADD153, and caspase-4, and subsequent tumor cell death.
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Specialized sorting of GLUT4 and its recruitment to the cell surface are independently regulated by distinct Rabs
TL;DR: RAB10 and RAB14 function at sequential steps of insulin-stimulated GLUT4 translocation to the plasma membrane, and R AB10 and its GAP protein comprise the main signaling module that regulates the accumulation of GLut4 transport vesicles at the plasma membranes.
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Human Insulin Vesicle Dynamics During Pulsatile Secretion
TL;DR: Using expressed fluorescent vesicle cargo proteins and total internal reflection fluorescence (TIRF) microscopy, it is demonstrated that glucose stimulates human pancreatic β-cells to secrete insulin vesicles in short, coordinated bursts of ∼70 vesicular cargo proteins each.
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Insulin-regulated Aminopeptidase Is a Key Regulator of GLUT4 Trafficking by Controlling the Sorting of GLUT4 from Endosomes to Specialized Insulin-regulated Vesicles
TL;DR: IRAP is a key regulator of GLUT4 trafficking by controlling sorting from endosomes to specialized insulin-regulated vesicles in patients with type 2 diabetes.