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Werner K. Lutz
Researcher at University of Würzburg
Publications - 153
Citations - 5625
Werner K. Lutz is an academic researcher from University of Würzburg. The author has contributed to research in topics: DNA damage & Genotoxicity. The author has an hindex of 43, co-authored 153 publications receiving 5425 citations. Previous affiliations of Werner K. Lutz include École Polytechnique Fédérale de Lausanne & University of Zurich.
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Journal ArticleDOI
In vivo covalent binding of organic chemicals to DNA as a quantitative indicator in the process of chemical carcinogenesis.
TL;DR: A comparison of CBI for rat-liver DNA with hepatocarcinogenic potency reveals a surprisingly good quantitative correlation and refineements for a DNA-binding assay are proposed.
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Essential function of p300 acetyltransferase activity in heart, lung and small intestine formation.
Noriko Shikama,Werner K. Lutz,Ralph Kretzschmar,Nadine S. Sauter,Jeanne-Françoise Roth,Silvia Marino,Jonas Wittwer,Alexander F. Scheidweiler,Richard Eckner +8 more
TL;DR: Unexpectedly, the p300 AT‐mutant cells upregulate BMP‐inducible genes to levels similar or even higher than observed in wild‐type cells.
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Differential role of p300 and CBP acetyltransferase during myogenesis: p300 acts upstream of MyoD and Myf5.
Jeanne-Françoise Roth,Noriko Shikama,Clea Henzen,Isabelle Desbaillets,Werner K. Lutz,Silvia Marino,Jonas Wittwer,Hubert Schorle,Max Gassmann,Richard Eckner +9 more
TL;DR: Genetic evidence is provided that p300 but not CBP acetyltransferase (AT) activity is required for myogenesis in the mouse and in embryonic stem (ES) cells and that ES cells lacking CBP AT activity express MyoD and Myf5 and undergo myogenic differentiation.
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BMI1 is a target gene of E2F-1 and is strongly expressed in primary neuroblastomas
Katrin Nowak,Kornelius Kerl,Daniel Fehr,Christoph Kramps,Christine Gessner,Katrin Killmer,Birgit Samans,Bernd Berwanger,Holger Christiansen,Werner K. Lutz +9 more
TL;DR: In neuroblastomas deregulated E2F-1 can activate two oncogenes, MYCN and BMI1 that are known to co-operate in tumor formation, and is consistent with a role of Bmi1 in neuroblastoma tumorigenesis.
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Genotoxicity of the laxative drug components emodin, aloe-emodin and danthron in mammalian cells: topoisomerase II mediated?
TL;DR: 1,8-Dihydroxyanthraquinones are under debate as plant-derived carcinogens that are found in laxatives, food colors, and possibly vegetables, and given clearcut evidence of their genotoxic activity, further research on the human cancer risk of these compounds may be warranted.