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Isabelle Desbaillets
Researcher at University of Zurich
Publications - 21
Citations - 3098
Isabelle Desbaillets is an academic researcher from University of Zurich. The author has contributed to research in topics: Glioma & Angiogenesis. The author has an hindex of 20, co-authored 21 publications receiving 3002 citations. Previous affiliations of Isabelle Desbaillets include University of Lausanne & University Hospital of Lausanne.
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Journal ArticleDOI
HIF-1 is expressed in normoxic tissue and displays an organ-specific regulation under systemic hypoxia
Deborah Stroka,Tobias Burkhardt,Isabelle Desbaillets,Roland H. Wenger,Desley Neil,Christian Bauer,Max Gassmann,Daniel Candinas +7 more
TL;DR: Immunohisto‐chemical examination of brain, kidney, liver, heart, and skeletal muscle revealed that HIF‐1α is present in mice kept under normoxic conditions and is further in‐creased in response to systemic hypoxia, suggesting that Hifer 1 has an important role in tissue homeostasis.
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Embryoid bodies: an in vitro model of mouse embryogenesis.
TL;DR: This review summarises the work on ES cell differentiation into haematopoietic and vascular cells, neuronal and glial cells, myocytes, and adipocytes, using this in vitro model of early embryogenesis and presents the potential of this method to analyse the impact of genetic alterations in vitro.
Journal Article
Classification of Human Astrocytic Gliomas on the Basis of Gene Expression A Correlated Group of Genes with Angiogenic Activity Emerges As a Strong Predictor of Subtypes
Sophie Godard,Gad Getz,Mauro Delorenzi,Pierre Farmer,Hiroyuki Kobayashi,Isabelle Desbaillets,Michimasa Nozaki,Annie-Claire Diserens,Marie-France Hamou,Pierre-Yves Dietrich,Luca Regli,Robert C. Janzer,Philipp Bucher,Roger Stupp,Nicolas de Tribolet,Eytan Domany,Monika E. Hegi,Monika E. Hegi +17 more
TL;DR: It is demonstrated that human gliomas can be differentiated according to their gene expression, and found that low-grade astrocytoma have the most specific and similar expression profiles, whereas primary glioblastoma exhibit much larger variation between tumors.
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Upregulation of Interleukin 8 by Oxygen-deprived Cells in Glioblastoma Suggests a Role in Leukocyte Activation, Chemotaxis, and Angiogenesis
Isabelle Desbaillets,Annie-Claire Diserens,Nicolas de Tribolet,Marie-France Hamou,Erwin G. Van Meir +4 more
TL;DR: In this article, the authors demonstrate expression of interleukin (IL)-8, a cytokine with chemotactic and angiogenic properties, and of IL-8-binding receptors in human astrocytoma.
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Differential role of p300 and CBP acetyltransferase during myogenesis: p300 acts upstream of MyoD and Myf5.
Jeanne-Françoise Roth,Noriko Shikama,Clea Henzen,Isabelle Desbaillets,Werner K. Lutz,Silvia Marino,Jonas Wittwer,Hubert Schorle,Max Gassmann,Richard Eckner +9 more
TL;DR: Genetic evidence is provided that p300 but not CBP acetyltransferase (AT) activity is required for myogenesis in the mouse and in embryonic stem (ES) cells and that ES cells lacking CBP AT activity express MyoD and Myf5 and undergo myogenic differentiation.