W
Wihelma Echevarria
Researcher at Yale University
Publications - 4
Citations - 949
Wihelma Echevarria is an academic researcher from Yale University. The author has contributed to research in topics: Voltage-dependent calcium channel & Nucleoplasmic reticulum. The author has an hindex of 4, co-authored 4 publications receiving 893 citations.
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Journal ArticleDOI
The orphan nuclear receptor, shp, mediates bile acid-induced inhibition of the rat bile acid transporter, ntcp.
Lee A. Denson,Ekkehard Sturm,Wihelma Echevarria,Tracy L. Zimmerman,Makoto Makishima,David J. Mangelsdorf,Saul J. Karpen +6 more
TL;DR: These studies show negative feedback regulation of ntcp by bile acid-activated fxr via induction of shp provides a means for coordinated down-regulation of bile acids import and synthesis, thereby protecting the hepatocyte from bile Acid-mediated damage in cholestatic conditions.
Journal ArticleDOI
Regulation of calcium signals in the nucleus by a nucleoplasmic reticulum
TL;DR: The findings show that the nucleus contains a nucleoplasmic reticulum with the capacity to regulate calcium signals in localized subnuclear regions and provides a potential mechanism by which calcium can simultaneously regulate many independent processes in the nucleus.
Journal ArticleDOI
Nuclear and cytosolic calcium are regulated independently
Maria de Fátima Leite,Edwin C. Thrower,Wihelma Echevarria,Peter Koulen,Keiji Hirata,Anton M. Bennett,Barbara E. Ehrlich,Michael H. Nathanson +7 more
TL;DR: Examining subcellular mechanisms of Ca2+ release in the HepG2 liver cell line found enriched expression of type II InsP3R in the nucleus results in greater sensitivity of the nucleus toInsP3, thus providing a mechanism for independent regulation of Ca1+-dependent processes in this cellular compartment.