W
Wilhelm Schoner
Researcher at University of Giessen
Publications - 123
Citations - 4041
Wilhelm Schoner is an academic researcher from University of Giessen. The author has contributed to research in topics: Na+/K+-ATPase & Ouabain. The author has an hindex of 33, co-authored 123 publications receiving 3962 citations. Previous affiliations of Wilhelm Schoner include University of Münster.
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Endogenous and exogenous cardiac glycosides: their roles in hypertension, salt metabolism, and cell growth
TL;DR: All data on the CTS-induced alteration of gene expression are consistent with another hypothesis, based on the Na(+)/K(+)-ATPase "signalosome," that describes the interaction of cardiac glycosides with the Na (+) pump as machinery activating various signaling pathways via intramembrane and cytosolic protein-protein interactions.
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Endogenous cardiac glycosides, a new class of steroid hormones
TL;DR: The discovery of ouabain as a new adrenal hormone affecting Na(+) metabolism and the development of the new ouABain antagonist PST 2238 allows for new possibilities for the therapy of hypertension and congestive heart failure.
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Endogenous and Exogenous Cardiac Glycosides and their Mechanisms of Action
TL;DR: Elevated concentrations of endogenous ouabain and marinobufagenin in the subnanomolar concentration range were found to stimulate proliferation and differentiation of cardiac and smooth muscle cells and may have a primary role in the development of cardiac dysfunction and failure.
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Ouabain-receptor interactions in (Na + +K + )-ATPase preparations from different tissues and species. Determination of kinetic constants and dissociation constants.
Erland Erdmann,Wilhelm Schoner +1 more
TL;DR: The stoichiometry of [3H]ouabain-binding sites: phosphorylated intermediate varied between 4 (guinea pig kidney) and 1 (beef enzymes), it is assumed that the ouabain receptor and the ATP hydrolysing subunit are not tightly linked.
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Bovine Adrenals Contain, in Addition to Ouabain, a Second Inhibitor of the Sodium Pump
Ralf Schneider,Victor Wray,Manfred Nimtz,Wolf Dieter Lehmann,Ulrike Kirch,Roberto Antolović,Wilhelm Schoner +6 more
TL;DR: Sodium pump inhibitor B from bovine adrenals is the cardenolide ouabain, which shows properties similar to the proscillaridin A immunoreactivity that increased in humans with systolic blood pressure and pulse pressure.