William C. Blackwelder

TL;DR: Pulmonary hypertension appears to be a complication of chronic hemolysis, is resistant to hydroxyurea therapy, and confers a high risk of death in adults with sickle cell disease.

TL;DR: Test statistics, confidence intervals, and sample size calculations are discussed, and the required sample size may be larger for either null hypothesis formulation than for the other, depending on the specific assumptions made.

TL;DR: The two acellular DTP vaccines studied were safe, immunogenic, and efficacious against pertussis, whereas the efficacy of the whole-cell DTP vaccine was unexpectedly low.

TL;DR: These data support a novel mechanism of disease in which hemolysis contributes to reduced nitric oxide bioavailability and endothelial dysfunction via release of erythrocyte arginase, which limits arginine bioavailability, and release of ______ hemoglobin, which scavengesNitric oxide.

TL;DR: The decline in influenza-related mortality among people aged 65 to 74 years in the decade after the 1968 pandemic is attributed to the acquisition of immunity to the emerging A(H3N2) virus, and observational studies substantially overestimate vaccination benefit.