Wynona Coles

TL;DR: Pulmonary hypertension appears to be a complication of chronic hemolysis, is resistant to hydroxyurea therapy, and confers a high risk of death in adults with sickle cell disease.

TL;DR: Data from this study support the implementation of echocardiographic screening of adult patients with SCD to identify high-risk individuals for further evaluation and contribute independently to prospective mortality in patients withSCD.

TL;DR: NO bioavailability and NO responsiveness are greater in women than in men with sickle cell disease and determines adhesion molecule expression and endothelium-dependent blood flows are largely non-NO mediated in male patients.

TL;DR: Among 30 patients with sickle cell phenotype with or without thalassemia who underwent nonmyeloablative allogeneic HSCT, the rate of stable mixed-donor chimerism was high and allowed for complete replacement with circulating donor red blood cells among engrafted participants.

TL;DR: Patients with SCD-associated PH have both pulmonary arterial and venous PH associated with severe limitations in exercise capacity, likely compounded by interstitial lung fibrosis and severe anemia, and the use of the six-minute-walk distance as an index of PH and cardiopulmonary function is supported.