W
William Dowhan
Researcher at University of Texas Health Science Center at Houston
Publications - 171
Citations - 15799
William Dowhan is an academic researcher from University of Texas Health Science Center at Houston. The author has contributed to research in topics: Cardiolipin & Membrane protein. The author has an hindex of 70, co-authored 169 publications receiving 14687 citations. Previous affiliations of William Dowhan include University of Melbourne & University of Texas System.
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Journal ArticleDOI
Membrane-associated phosphatidylglycerophosphate synthetase from Escherichia coli: purification by substrate affinity chromatography on cytidine 5'-diphospho-1,2-diacyl-sn-glycerol sepharose.
TL;DR: Kinetic analysis of the enzymatic reaction indicated an ordered sequential Bi-Bi reaction with the liponucleotide forming a dead-end complex at high concentration, which inhibited both the forward and reverse reactions.
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A retrospective: use of Escherichia coli as a vehicle to study phospholipid synthesis and function.
TL;DR: The findings that have led to the development of E. coli as an excellent model system to study mechanisms underlying the synthesis and function of phospholipids that are widely applicable to other prokaryotic and eukaryotic systems are traced.
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Isolation of a chinese hamster ovary (CHO) cDNA encoding phosphatidylglycerophosphate (PGP) synthase, expression of which corrects the mitochondrial abnormalities of a PGP synthase-defective mutant of CHO-K1 cells.
Kiyoshi Kawasaki,Kiyoshi Kawasaki,Osamu Kuge,Shao Chun Chang,Philip Heacock,Minseok Rho,Kenji Suzuki,Masahiro Nishijima,William Dowhan +8 more
TL;DR: It is demonstrated that the morphological and functional defects displayed by the PGS-S mutant are due directly to the reduced ability to make normal levels of PG and/or CL.
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The Escherichia coli pgpB Gene Encodes for a Diacylglycerol Pyrophosphate Phosphatase Activity
TL;DR: Genetic and biochemical evidence was provided that supported the conclusion that the product of pgpB gene of Escherichia coli exhibited diacylglycerol pyrophosphate (DGPP) phosphatase activity.
Lipids in the Assembly of Membrane Proteins and Organization of Protein Supercomplexes
TL;DR: In this paper, the role of phosphatidylethanolamine and cardiolipin in normal assembly and organization of the membrane proteins, multimeric protein complexes, and higher order supercomplexes is discussed.