W
William Dowhan
Researcher at University of Texas Health Science Center at Houston
Publications - 171
Citations - 15799
William Dowhan is an academic researcher from University of Texas Health Science Center at Houston. The author has contributed to research in topics: Cardiolipin & Membrane protein. The author has an hindex of 70, co-authored 169 publications receiving 14687 citations. Previous affiliations of William Dowhan include University of Melbourne & University of Texas System.
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Journal ArticleDOI
Cdp-diacylglycerol synthase of microorganisms
TL;DR: Evidence now exists from studies in Drosophila that this liponucleotide may be important in regulation of lipid-dependent signal transduction processes and led to the cloning of genes that encode CDP-diacylglycerol synthases from somatic cells.
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Proper fatty acid composition rather than an ionizable lipid amine is required for full transport function of lactose permease from Escherichia coli.
TL;DR: A close correlation was observed in vivo and in vitro between the ability of LacY to carry out uphill transport, the native conformation of P7, and the lipid headgroup and fatty acid composition oflipids, further illustrating the direct role of lipids, independent of other cellular factors, in defining membrane protein structure/function.
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Phosphatidylinositol cannot substitute for phosphatidylglycerol in supporting cell growth of Escherichia coli.
Weiming Xia,William Dowhan +1 more
TL;DR: Escherichia coli cells are dependent on the anionic phospholipid phosphatidylglycerol for cell growth, but introduction into cells of the ability to make phosph atidylinositol did not suppress the need for naturally occurring phosphorus.
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Mutual effects of MinD-membrane interaction: I. Changes in the membrane properties induced by MinD binding
Shirley Mazor,Tomer Regev,Eugenia Mileykovskaya,William Margolin,William Dowhan,Itzhak Fishov +5 more
TL;DR: The mobility of pyrene-labeled phosphatidylglycerol indicated formation of acidic phospholipid-enriched domains in a mixed acidic-zwitterionic membrane at specific MinD/phospholipids ratios.
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Biosynthetic preparation of selectively deuterated phosphatidylcholine in genetically modified Escherichia coli
Selma Maric,Mikkel B. Thygesen,Jürgen Schiller,Magdalena Marek,Martine Moulin,Michael Haertlein,V. Trevor Forsyth,Mikhail Bogdanov,William Dowhan,Lise Arleth,Thomas Günther Pomorski +10 more
TL;DR: This biosynthetic approach paves the way for the synthesis of specifically deuterated, physiologically relevant phospholipid species which remain difficult to obtain through standard chemical synthesis.