William J. M. Hrushesky

TL;DR: This is the first human study to show a circadian profile of expression for all five clock genes as documented in rodents, suggesting their functional importance in man.

TL;DR: The idea that surgical cancer resection has both beneficial and adverse effects upon cancer spread and growth that result from the modulation of tumor dormancy by the resection should be considered a potentially fruitful working hypothesis.

TL;DR: The evolution of the paradigms described herein is supported by a growing body of findings from experimental models, and is required to explain breast cancer recurrence dynamics for patients undergoing surgery with or without adjuvant chemotherapy.

TL;DR: This historical perspective on breast cancer tells us how and why certain therapeutic eras have reached ascendancy and then declined and why a new crisis is upon us now in that trials of early detection have resulted in unexpected disadvantages to certain subgroups and clinical data that suggests the act of surgery might accelerate the appearance of distant metastases.

TL;DR: The data suggest that Per2 gene product suppresses tumorigenesis in the small intestine and colon by down-regulation of β-catenin and β-Catenin target genes, and this circadian core clock gene may represent a novel target for colorectal cancer prevention and control.