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William J. Welsh
Researcher at Rutgers University
Publications - 135
Citations - 6832
William J. Welsh is an academic researcher from Rutgers University. The author has contributed to research in topics: Pregnane X receptor & Virtual screening. The author has an hindex of 41, co-authored 135 publications receiving 6340 citations. Previous affiliations of William J. Welsh include University of Medicine and Dentistry of New Jersey & Enzon Pharmaceuticals, Inc..
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Tea Polyphenol (−)-Epigallocatechin-3-Gallate Inhibits DNA Methyltransferase and Reactivates Methylation-Silenced Genes in Cancer Cell Lines
TL;DR: It is reported herein that (-)-epigallocatechin-3-gallate (EGCG), the major polyphenol from green tea, can inhibit DNMT activity and reactivate methylation-silenced genes in cancer cells and the potential use of EGCG for the prevention or reversal of related gene-silencing in the prevention of carcinogenesis is suggested.
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Online chemical modeling environment (OCHEM): web platform for data storage, model development and publishing of chemical information
Iurii Sushko,Sergii Novotarskyi,Robert Körner,Anil Kumar Pandey,Matthias Rupp,Wolfram Teetz,Stefan Brandmaier,Ahmed Abdelaziz,Volodymyr V. Prokopenko,Vsevolod Yu. Tanchuk,Roberto Todeschini,Alexandre Varnek,Gilles Marcou,Peter Ertl,Vladimir Potemkin,Maria Grishina,Johann Gasteiger,Christof H. Schwab,Igor I. Baskin,Vladimir A. Palyulin,Eugene V. Radchenko,William J. Welsh,Vladyslav Kholodovych,Dmitriy Chekmarev,Artem Cherkasov,João Aires-de-Sousa,Qingyou Zhang,Andreas Bender,Florian Nigsch,Luc Patiny,Antony J. Williams,Valery Tkachenko,Igor V. Tetko +32 more
TL;DR: The Online Chemical Modeling Environment is a web-based platform that aims to automate and simplify the typical steps required for QSAR modeling and to invite the original authors to contribute their results, make them publicly available, share them with other users and to become members of the growing research community.
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Quantitative structure‐activity relationship methods: Perspectives on drug discovery and toxicology
TL;DR: This review attempts to summarize the status of QSAR with emphasis on illuminating the utility and limitations ofQSAR technology, and compares the relative suitability of 2D and 3D QS AR for different applications.
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Gaussian mixture clustering and imputation of microarray data
TL;DR: The Gaussian mixture clustering with model averaging imputation is superior to all other imputation methods, according to both evaluation metrics, on both time-series (cor related) and non-time series (uncorrelated) data sets.
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Bisphenol A and its analogues activate human pregnane X receptor.
Yipeng Sui,Ni Ai,Se-Hyung Park,Jennifer Rios-Pilier,Jordan T. Perkins,William J. Welsh,Changcheng Zhou +6 more
TL;DR: Understanding is advanced of the mechanism by which BPA interacts with and activates human PXR, and key residues within hPXR’s ligand-binding pocket that constitute points of interaction with BPA are identified.