V
Vladyslav Kholodovych
Researcher at Rutgers University
Publications - 44
Citations - 2024
Vladyslav Kholodovych is an academic researcher from Rutgers University. The author has contributed to research in topics: Pregnane X receptor & Biguanide. The author has an hindex of 23, co-authored 42 publications receiving 1734 citations. Previous affiliations of Vladyslav Kholodovych include Rutgers Biomedical and Health Sciences & University of Medicine and Dentistry of New Jersey.
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Online chemical modeling environment (OCHEM): web platform for data storage, model development and publishing of chemical information
Iurii Sushko,Sergii Novotarskyi,Robert Körner,Anil Kumar Pandey,Matthias Rupp,Wolfram Teetz,Stefan Brandmaier,Ahmed Abdelaziz,Volodymyr V. Prokopenko,Vsevolod Yu. Tanchuk,Roberto Todeschini,Alexandre Varnek,Gilles Marcou,Peter Ertl,Vladimir Potemkin,Maria Grishina,Johann Gasteiger,Christof H. Schwab,Igor I. Baskin,Vladimir A. Palyulin,Eugene V. Radchenko,William J. Welsh,Vladyslav Kholodovych,Dmitriy Chekmarev,Artem Cherkasov,João Aires-de-Sousa,Qingyou Zhang,Andreas Bender,Florian Nigsch,Luc Patiny,Antony J. Williams,Valery Tkachenko,Igor V. Tetko +32 more
TL;DR: The Online Chemical Modeling Environment is a web-based platform that aims to automate and simplify the typical steps required for QSAR modeling and to invite the original authors to contribute their results, make them publicly available, share them with other users and to become members of the growing research community.
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Human Pregnane X Receptor Antagonists and Agonists Define Molecular Requirements for Different Binding Sites
Sean Ekins,Cheng Chang,Sridhar Mani,Matthew D. Krasowski,Erica J. Reschly,Manisha Iyer,Vladyslav Kholodovych,Ni Ai,William J. Welsh,Michael Sinz,Peter W. Swaan,Rachana Patel,Kenneth Bachmann +12 more
TL;DR: Combining computational and experimental data for different classes of molecules provided strong evidence for agonists and antagonists binding distinct regions on PXR, and bear significant implications for future discovery of molecules that are more selective and potent antagonists.
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Highly chlorinated PCBs inhibit the human xenobiotic response mediated by the steroid and xenobiotic receptor (SXR).
Michelle M. Tabb,Vladyslav Kholodovych,Felix Grün,Changcheng Zhou,William J. Welsh,Bruce Blumberg +5 more
TL;DR: It is found that certain highly chlorinated PCBs are potent activators of rodent PXR but antagonize its human ortholog, the steroid and xenobiotic receptor (SXR), inhibiting target gene induction.
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Sugar-based amphiphilic nanoparticles arrest atherosclerosis in vivo
Daniel R. Lewis,Latrisha K. Petersen,Adam W. York,Kyle Zablocki,Laurie B. Joseph,Vladyslav Kholodovych,Robert K. Prud'homme,Kathryn E. Uhrich,Prabhas V. Moghe +8 more
TL;DR: This work presents a nanomedicine platform to counteract plaque development based on two building blocks, and demonstrates the design principles necessary to prevent oxidized lipid uptake and suppress scavenger receptor expression in macrophages, switching them to an “atheroprotective” phenotype.
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Tumor-targeted bioconjugate based delivery of camptothecin: design, synthesis and in vitro evaluation.
Pankaj V. Paranjpe,Yu Chen,Vladyslav Kholodovych,William J. Welsh,Stanley Stein,Patrick J. Sinko +5 more
TL;DR: ThisBioconjugate represents the 'first-in-series' of targeted bioconjugates and serves as prototype for improving tumor cell concentration and efficacy and serving as prototype to optimize the delivery of CPT using an endogenous receptor system.