William McKleroy

TL;DR: A critical role is demonstrated for Mfge8 in decreasing the severity of murine tissue fibrosis by facilitating the removal of accumulated collagen through binding and targeting collagen for cellular uptake through its discoidin domains.

TL;DR: The objective of this review is to evaluate the roles of the extracellular and intracellular collagen degradation pathways in the development of fibrosis and to examine whether pulmonary fibrosis can be viewed as a disease of impaired matrix degradation rather than a Disease of increased matrix production.

TL;DR: It is shown that Mfge8 promotes the absorption of dietary triglycerides and the cellular uptake of fatty acid and that M fge8-deficient mice are protected from diet-induced obesity, steatohepatitis and insulin resistance and imply a role for Mf ge8 in regulating the absorption and storage of dietary fats, as well as in the development of obesity and its complications.

TL;DR: The authors conclude that isoflurane does not cause cell death, but it does act directly on neural progenitor cells independently of effects on the surrounding brain to decrease proliferation and increase neuronal fate selection.

TL;DR: The data indicate that Mfge8 binding to integrin receptors on ASM opposes the effect of allergic inflammation on RhoA activity and identifies a pathway for specific inhibition of ASM hypercontractility in asthma.