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William P. Clarke
Researcher at University of Texas Health Science Center at San Antonio
Publications - 84
Citations - 5101
William P. Clarke is an academic researcher from University of Texas Health Science Center at San Antonio. The author has contributed to research in topics: Receptor & Agonist. The author has an hindex of 36, co-authored 79 publications receiving 4817 citations. Previous affiliations of William P. Clarke include University of Texas at Austin & Northeastern University.
Papers
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Journal ArticleDOI
Functional Selectivity and Classical Concepts of Quantitative Pharmacology
Jonathan D. Urban,William P. Clarke,Mark von Zastrow,David E. Nichols,Brian K. Kobilka,Harel Weinstein,Jonathan A. Javitch,Bryan L. Roth,Arthur Christopoulos,Patrick M. Sexton,Keith J. Miller,Michael Spedding,Richard B. Mailman +12 more
TL;DR: Besides the heuristically interesting nature of functional selectivity, there is a clear impact on drug discovery, because this mechanism raises the possibility of selecting or designing novel ligands that differentially activate only a subset of functions of a single receptor, thereby optimizing therapeutic action.
Journal ArticleDOI
Effector pathway-dependent relative efficacy at serotonin type 2a and 2c receptors : evidence for agonist-directed trafficking of receptor stimulus
TL;DR: Concentration-response curves to 5-HT2C agonists were fit well by a three-state model of receptor activation, suggesting that two active receptor states may be sufficient to explain pathway-dependent agonist efficacy.
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Constitutive Activity of the Serotonin2C Receptor Inhibits In Vivo Dopamine Release in the Rat Striatum and Nucleus Accumbens
Philippe De Deurwaerdère,Sylvia Navailles,Kelly A. Berg,William P. Clarke,Umberto Spampinato +4 more
TL;DR: First in vivo evidence that constitutive activity of the 5-HT2C receptor tonically inhibits mesencephalic DA neurons is provided and underscores the need for a better understanding of the pathophysiological role of constitutive receptor activity.
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Bradykinin-Induced Functional Competence and Trafficking of the δ-Opioid Receptor in Trigeminal Nociceptors
Amol M. Patwardhan,Kelly A. Berg,Armen N. Akopain,Nathaniel A. Jeske,Nikita Gamper,William P. Clarke,Kenneth M. Hargreaves +6 more
TL;DR: It is suggested that exposure to certain inflammatory mediators rapidly alters the signaling properties and neuronal localization of DOR, possibly contributing to peripheral opioid analgesia.
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RNA-editing of the 5-HT(2C) receptor alters agonist-receptor-effector coupling specificity.
Kelly A. Berg,Jodie Cropper,Colleen M. Niswender,Elaine Sanders-Bush,Ronald B. Emeson,William P. Clarke +5 more
TL;DR: An important role for the second intracellular loop in transmitting agonist‐specific information to signalling molecules is suggested in transmitting receptor stimulus to transducer molecules.