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Sylvia Navailles
Researcher at University of Bordeaux
Publications - 41
Citations - 2371
Sylvia Navailles is an academic researcher from University of Bordeaux. The author has contributed to research in topics: Dopamine & Striatum. The author has an hindex of 24, co-authored 40 publications receiving 2190 citations. Previous affiliations of Sylvia Navailles include Université Bordeaux Segalen & Centre national de la recherche scientifique.
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Journal ArticleDOI
Pathophysiology of L-dopa-induced motor and non-motor complications in Parkinson's disease.
Matthieu F. Bastide,Wassilios G. Meissner,Barbara Picconi,Stefania Fasano,Pierre-Olivier Fernagut,Michael Feyder,Veronica Francardo,Cristina Alcacer,Yunmin Ding,Riccardo Brambilla,Gilberto Fisone,A. Jon Stoessl,Mathieu Bourdenx,Michel Engeln,Sylvia Navailles,Philippe De Deurwaerdère,Wai Kin D. Ko,Nicola Simola,Micaela Morelli,Laurent Groc,Maria Cruz Rodriguez,Eugenia V. Gurevich,Maryka Quik,Michele Morari,Manuela Mellone,Fabrizio Gardoni,Elisabetta Tronci,Dominique Guehl,François Tison,Alan R. Crossman,Un Jung Kang,Kathy Steece-Collier,Susan H. Fox,Manolo Carta,M. Angela Cenci,Erwan Bezard +35 more
TL;DR: The present review attempts to provide an overview of the current understanding of dyskinesia and other L-dopa-induced dysfunctions to help in the development of novel therapeutic strategies aimed at preventing the generation of dyskinetic symptoms.
Journal ArticleDOI
Constitutive Activity of the Serotonin2C Receptor Inhibits In Vivo Dopamine Release in the Rat Striatum and Nucleus Accumbens
Philippe De Deurwaerdère,Sylvia Navailles,Kelly A. Berg,William P. Clarke,Umberto Spampinato +4 more
TL;DR: First in vivo evidence that constitutive activity of the 5-HT2C receptor tonically inhibits mesencephalic DA neurons is provided and underscores the need for a better understanding of the pathophysiological role of constitutive receptor activity.
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Serotonergic neurons mediate ectopic release of dopamine induced by l-DOPA in a rat model of Parkinson's disease
TL;DR: Using microdialysis in a rat model of Parkinson's disease, it is found that l-DOPA increased dopamine extracellular levels monitored simultaneously in four brain regions receiving serotonergic innervation: striatum, substantia nigra, hippocampus, prefrontal cortex, and the increase was regionally similar at the lowest dose and 2-3 times stronger in the striatum at higher doses.
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Differential regulation of the mesoaccumbens dopamine circuit by serotonin2C receptors in the ventral tegmental area and the nucleus accumbens: an in vivo microdialysis study with cocaine.
TL;DR: The idea that the overall action of central 5-HT2CRs on accumbal DA output is dependent, at least in part, on the functional balance between different 5- HT2CR populations within the NAc and within the mesoaccumbens DA pathway (VTA vs NAc) is supported.
Journal ArticleDOI
Presynaptic control of serotonin on striatal dopamine function
TL;DR: A thorough examination of data showing controversial effects induced by striatal 5-HT on dopaminergic activity suggests that the endogenous 5- HT system exerts multiple and subtle influences on DA-mediated behaviors.