W
William R. Swindell
Researcher at Jewish Hospital
Publications - 78
Citations - 4889
William R. Swindell is an academic researcher from Jewish Hospital. The author has contributed to research in topics: Psoriasis & Gene expression profiling. The author has an hindex of 32, co-authored 72 publications receiving 3851 citations. Previous affiliations of William R. Swindell include University of Michigan & Heritage College of Osteopathic Medicine.
Papers
More filters
Journal ArticleDOI
Modulation of Epidermal Transcription Circuits in Psoriasis: New Links between Inflammation and Hyperproliferation
William R. Swindell,Andrew Johnston,Xianying Xing,John J. Voorhees,James T. Elder,Johann E. Gudjonsson +5 more
TL;DR: A new approach for delineating epidermis-specific pathways and regulatory mechanisms that underlie altered gene expression in psoriasis is developed and highlights previously unrecognized “transcription circuits” that can provide targets for development of non-systemic therapies.
Journal ArticleDOI
Indicators of "Healthy Aging" in older women (65-69 years of age). A data-mining approach based on prediction of long-term survival
William R. Swindell,Kristine E. Ensrud,Peggy M. Cawthon,Jane A. Cauley,Steve Cummings,Richard A. Miller +5 more
TL;DR: The multivariable model developed characterizes a "healthy aging" phenotype based upon an integration of measures that together reflect multiple dimensions of an aging adult (65-69 years of age) and may be of value as biomarkers in human studies that evaluate anti-aging interventions.
Journal ArticleDOI
Cellular dissection of psoriasis for transcriptome analyses and the post-GWAS era
William R. Swindell,Philip E. Stuart,Mrinal K. Sarkar,John J. Voorhees,James T. Elder,Andrew Johnston,Johann E. Gudjonsson +6 more
TL;DR: This paper identified differentially expressed genes (DEGs) with altered expression in psoriasis lesions (n = 216 patients), as well as candidate genes near susceptibility loci from GWAS studies, and proposed an approach for generating hypotheses to explain GWAS hits at intergenic loci.
Journal ArticleDOI
A GRHL3-regulated repair pathway suppresses immune-mediated epidermal hyperplasia
William Gordon,Michael Zeller,Rachel Herndon Klein,William R. Swindell,Hsiang Ho,Francisco Espetia,Johann E. Gudjonsson,Pierre Baldi,Bogi Andersen +8 more
TL;DR: It is determined that the prodifferentiation transcription factor grainyhead-like 3 (GRHL3), which is essential during epidermal development, is dispensable for adult skin homeostasis, but required for barrier repair after adult epidersmal injury.
Journal ArticleDOI
Early tissue responses in psoriasis to the antitumour necrosis factor-α biologic etanercept suggest reduced interleukin-17 receptor expression and signalling.
Andrew Johnston,Andrew M. Guzman,William R. Swindell,Frank Wang,Sewon Kang,Johann E. Gudjonsson +5 more
TL;DR: Antitumour necrosis factor (anti‐TNF)‐α therapy has made a significant impact on the treatment of psoriasis despite these agents being designed to neutralize TNF‐α activity.