J
Johann E. Gudjonsson
Researcher at University of Michigan
Publications - 196
Citations - 7365
Johann E. Gudjonsson is an academic researcher from University of Michigan. The author has contributed to research in topics: Psoriasis & Inflammation. The author has an hindex of 40, co-authored 196 publications receiving 4779 citations.
Papers
More filters
Journal ArticleDOI
Atopic Dermatitis Is an IL-13–Dominant Disease with Greater Molecular Heterogeneity Compared to Psoriasis
Lam C. Tsoi,Elke Rodriguez,Frauke Degenhardt,Hansjörg Baurecht,Ulrike Wehkamp,Natalie Volks,Silke Szymczak,William R. Swindell,Mrinal K. Sarkar,Kalpana Raja,Shuai Shao,Matthew Patrick,Yilin Gao,Ranjitha Uppala,Bethany E. Perez White,Spiro Getsios,Paul W. Harms,Emanual Michael Maverakis,James T. Elder,James T. Elder,Andre Franke,Johann E. Gudjonsson,Stephan Weidinger +22 more
TL;DR: This study is by far the largest study comparing the AD and psoriasis transcriptomes using RNA sequencing and demonstrating the shared inflammatory components, as well as specific discordant cytokine signatures of these two skin diseases.
Journal ArticleDOI
Large scale meta-analysis characterizes genetic architecture for common psoriasis associated variants
Lam C. Tsoi,Philip E. Stuart,Chao Tian,Johann E. Gudjonsson,Sayantan Das,Matthew Zawistowski,Eva Ellinghaus,Jonathan Barker,Vinod Chandran,Nick Dand,Kristina Callis Duffin,Charlotta Enerbäck,Tõnu Esko,Tõnu Esko,Andre Franke,Dafna D. Gladman,Per Hoffmann,Per Hoffmann,Külli Kingo,Sulev Kõks,Sulev Kõks,Gerald G. Krueger,Henry W. Lim,Andres Metspalu,Ulrich Mrowietz,Sören Mucha,Proton Rahman,André Reis,Trilokraj Tejasvi,Trilokraj Tejasvi,Richard C. Trembath,John J. Voorhees,Stephan Weidinger,Michael Weichenthal,Xiaoquan Wen,Nicholas Eriksson,Hyun Min Kang,David A. Hinds,Rajan P. Nair,Gonçalo R. Abecasis,James T. Elder,James T. Elder +41 more
TL;DR: This study provides a comprehensive layout for the genetic architecture of common variants for psoriasis, including data from eight different Caucasian cohorts, with a combined effective sample size >39,000 individuals.
Journal ArticleDOI
IL-36 promotes myeloid cell infiltration, activation and inflammatory activity in skin
Alexander M. Foster,Jaymie Baliwag,Cynthia S. Chen,Andrew M. Guzman,Stefan W. Stoll,Johann E. Gudjonsson,Nicole L. Ward,Andrew Johnston +7 more
TL;DR: IL-36 cytokines actively propagate skin inflammation via the activation of keratinocytes, APC, and, indirectly, T cells as well as stimulating the maturation and function of DC and drive T cell proliferation.
Journal ArticleDOI
IL-1 and IL-36 are dominant cytokines in generalized pustular psoriasis
Andrew Johnston,Xianying Xing,Liza Wolterink,Drew H. Barnes,Z. Yin,Z. Yin,Laura J. Reingold,J. Michelle Kahlenberg,Paul W. Harms,Johann E. Gudjonsson +9 more
TL;DR: Sustained activation of IL‐1 and IL‐36 in GPP is indicated, inducing neutrophil chemokine expression, infiltration, and pustule formation, suggesting that the IL-1/IL‐36 inflammatory axis is a potent driver of disease pathology in G PP.
Journal ArticleDOI
Analysis of long non-coding RNAs highlights tissue-specific expression patterns and epigenetic profiles in normal and psoriatic skin
Lam C. Tsoi,Matthew K. Iyer,Philip E. Stuart,William R. Swindell,Johann E. Gudjonsson,Trilokraj Tejasvi,Mrinal K. Sarkar,Bingshan Li,Bingshan Li,Jun Ding,Jun Ding,John J. Voorhees,Hyun Min Kang,Rajan P. Nair,Arul M. Chinnaiyan,Gonçalo R. Abecasis,James T. Elder +16 more
TL;DR: It is found that many lncRNAs, in particular those that are differentially expressed, are co-expressed with genes involved in immune related functions, and that novel lnc RNAs are enriched for localization in the epidermal differentiation complex.