W
William Gordon
Researcher at Pfizer
Publications - 34
Citations - 4827
William Gordon is an academic researcher from Pfizer. The author has contributed to research in topics: Cellular differentiation & Transcription factor. The author has an hindex of 21, co-authored 34 publications receiving 4194 citations. Previous affiliations of William Gordon include Harvard University & Massachusetts Institute of Technology.
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Journal ArticleDOI
Concurrent Chemotherapy and Pelvic Radiation Therapy Compared With Pelvic Radiation Therapy Alone as Adjuvant Therapy After Radical Surgery in High-Risk Early-Stage Cancer of the Cervix
William A. Peters,P. Y. Liu,Rolland J. Barrett,Richard J. Stock,Bradley J. Monk,Jonathan S. Berek,Luis Souhami,Perry Grigsby,William Gordon,David S. Alberts +9 more
TL;DR: The addition of concurrent cisplatin-based CT to RT significantly improves progression-free and overall survival for high-risk, early-stage patients who undergo radical hysterectomy and pelvic lymphadenectomy for carcinoma of the cervix.
Journal ArticleDOI
Tissue-specific transcriptional regulation has diverged significantly between human and mouse.
Duncan T. Odom,Robin D. Dowell,Elizabeth S Jacobsen,William Gordon,Timothy Danford,Kenzie D MacIsaac,P. Alexander Rolfe,Caitlin M. Conboy,David K. Gifford,Ernest Fraenkel +9 more
TL;DR: It is demonstrated that the binding sites for highly conserved transcription factors vary extensively between human and mouse, and from 41% to 89% of their binding events seem to be species specific.
Journal ArticleDOI
Concurrent Chemotherapy and Pelvic Radiation Therapy Compared With Pelvic Radiation Therapy Alone as Adjuvant Therapy After Radical Surgery in High-Risk Early-Stage Cancer of the Cervix
William A. Peters,P. Y. Liu,Rolland J. Barrett,Richard J. Stock,Bradley J. Monk,Jonathan S. Berek,Luis Souhami,Perry Grigsby,William Gordon,David S. Alberts +9 more
TL;DR: In this paper, the authors evaluated whether the addition of cisplatin-based chemotherapy (CT) to pelvic radiation therapy (RT) will improve the survival of early-stage, high-risk patients with cervical carcinoma.
Journal ArticleDOI
Brain and muscle Arnt-like protein-1 (BMAL1) controls circadian cell proliferation and susceptibility to UVB-induced DNA damage in the epidermis
Mikhail Geyfman,Vivek Kumar,Qiang Liu,Rolando Ruiz,William Gordon,Francisco Espitia,Eric Cam,Sarah E. Millar,Padhraic Smyth,Alexander T. Ihler,Joseph S. Takahashi,Bogi Andersen +11 more
TL;DR: It is speculated that in humans the circadian clock imposes regulation of epidermal cell proliferation so that skin is at a particularly vulnerable stage during times of maximum UV exposure, thus contributing to the high incidence of human skin cancers.
Journal ArticleDOI
Rethinking the use of radiation and chemotherapy after radical hysterectomy: a clinical-pathologic analysis of a Gynecologic Oncology Group/Southwest Oncology Group/Radiation Therapy Oncology Group trial.
Bradley J. Monk,Jianmin Wang,Samuel Im,Richard J. Stock,Richard J. Stock,William A. Peters,P. Y. Liu,Rolland J. Barrett,Jonathan S. Berek,Luis Souhami,Perry W. Grigsby,William Gordon,David S. Alberts +12 more
TL;DR: Adding CT to RT after radical hysterectomy appears to provide a smaller absolute benefit when only one node is positive or when the tumor size is < 2 cm, according to this exploratory, hypothesis-generating analysis.