Wim Van Schooten

TL;DR: It is demonstrated that senescence-induced inflammation promotes accumulation of CD38 in immune cells that, through its ecto-enzymatic activity, decreases levels of NMN and NAD+.

TL;DR: Inflammatory skin T cells were cloned in an antigen‐independent way from lesions of patients with experimentally induced nickel‐contact dermatitis and 5 out of 8 nickel‐specific TLC exclusively recognized nickel when presented by these skin‐specific APC whereas 3 out of these 8 clones could also recognize nickel presented by APC from peripheral blood.

TL;DR: A bacterial artificial chromosome library was created using partially digested rabbit chromosomal DNA to study the organization of the rabbit immunoglobulin (Ig) heavy chain locus and the potential function of newly identified functional and structural elements.

TL;DR: In this article, the authors present methods and means to produce humanized antibodies from transgenic non-human animals using immunoglobulin heavy and light chain constructs, recombination and transgenic vectors.

TL;DR: The presence of Ig‐ or Ig‐antigen complex‐reactive T cells in arthritic joints implies that B cells expressing anti‐Ig antibody may play an important role in antigen presentation to autore active T cells.