J
John W. Calvert
Researcher at Emory University
Publications - 126
Citations - 10346
John W. Calvert is an academic researcher from Emory University. The author has contributed to research in topics: Reperfusion injury & Cardioprotection. The author has an hindex of 49, co-authored 119 publications receiving 9261 citations. Previous affiliations of John W. Calvert include Yeshiva University & University of Mississippi Medical Center.
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Journal ArticleDOI
Hydrogen sulfide attenuates myocardial ischemia-reperfusion injury by preservation of mitochondrial function
John W. Elrod,John W. Calvert,Joanna Morrison,Jeannette E. Doeller,David W. Kraus,Ling Tao,Xiangying Jiao,Rosario Scalia,Levente Kiss,Csaba Szabó,Hideo Kimura,Chi Wing Chow,David J. Lefer +12 more
TL;DR: It is demonstrated that the delivery of H2S at the time of reperfusion limits infarct size and preserves left ventricular (LV) function in an in vivo model of myocardial ischemia-reperfusion (MI-R) and that either administration of H 2S or the modulation of endogenous production may be of clinical benefit in ischemic disorders.
Journal ArticleDOI
Hydrogen Sulfide Mediates Cardioprotection Through Nrf2 Signaling
John W. Calvert,Saurabh Jha,Susheel Gundewar,John W. Elrod,Arun Ramachandran,Christopher B. Pattillo,Christopher G. Kevil,David J. Lefer +7 more
TL;DR: Results reveal that the cardioprotective effects of H2S are mediated in large part by a combination of antioxidant and antiapoptotic signaling.
Journal ArticleDOI
Nitrite augments tolerance to ischemia/reperfusion injury via the modulation of mitochondrial electron transfer
Sruti Shiva,Michael N. Sack,James J. M. Greer,Mark R. Duranski,Lorna A. Ringwood,Lindsay S. Burwell,Xunde Wang,Peter H. MacArthur,Amir Shoja,Nalini Raghavachari,John W. Calvert,Paul S. Brookes,David J. Lefer,Mark T. Gladwin +13 more
TL;DR: It is reported that both acute and delayed exposure to physiological concentrations of nitrite, given both systemically or orally, potently limits cardiac and hepatic reperfusion injury and may represent an effector of the cell-survival program of ischemic preconditioning and the Mediterranean diet.
Journal ArticleDOI
Acute Metformin Therapy Confers Cardioprotection Against Myocardial Infarction Via AMPK-eNOS–Mediated Signaling
John W. Calvert,Susheel Gundewar,Saurabh Jha,James J. M. Greer,William H. Bestermann,Rong Tian,David J. Lefer +6 more
TL;DR: These findings provide important information that myocardial AMPK activation by metformin following I/R sets into motion events, including eNOS activation, which ultimately lead to cardioprotection.
Journal ArticleDOI
Activation of AMP-Activated Protein Kinase by Metformin Improves Left Ventricular Function and Survival in Heart Failure
Susheel Gundewar,John W. Calvert,Saurabh Jha,Iris Toedt-Pingel,Sang Yong Ji,Denise Nunez,Arun Ramachandran,Mauricio Anaya-Cisneros,Rong Tian,David J. Lefer,David J. Lefer +10 more
TL;DR: It is demonstrated that metformin significantly improves left ventricular function and survival via activation of AMPK and its downstream mediators, eNOS and PGC-1&agr;, in a murine model of heart failure.