W
Wolfram Petzl
Researcher at Ludwig Maximilian University of Munich
Publications - 45
Citations - 1996
Wolfram Petzl is an academic researcher from Ludwig Maximilian University of Munich. The author has contributed to research in topics: Mastitis & Staphylococcus aureus. The author has an hindex of 19, co-authored 43 publications receiving 1694 citations.
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Journal ArticleDOI
Host-response patterns of intramammary infections in dairy cows
Ynte H. Schukken,Juliane Günther,Julie Lydia Fitzpatrick,Michael C. Fontaine,Leopold Goetze,Otto Holst,James A. Leigh,Wolfram Petzl,Hans-Joachim Schuberth,Anja Sipka,David Smith,Rebecca R. Quesnell,Jeffrey L. Watts,Robert J. Yancey,Holm Zerbe,A. Gurjar,Ruth N. Zadoks,Hans-Martin Seyfert +17 more
TL;DR: The pathogen specific response to the three main bacterial species causing bovine mastitis: Escherichia coli, Streptococcus uberis and Staphylococcus aureus is evaluated.
Journal ArticleDOI
Bovine TLR2 and TLR4 properly transduce signals from Staphylococcus aureus and E. coli, but S. aureus fails to both activate NF-kappaB in mammary epithelial cells and to quickly induce TNFalpha and interleukin-8 (CXCL8) expression in the udder.
Wei Yang,Holm Zerbe,Wolfram Petzl,Ronald M. Brunner,Juliane Günther,Christian Draing,Sonja von Aulock,Hans-Joachim Schuberth,Hans-Martin Seyfert +8 more
TL;DR: The results prove that impaired binding of TLR-ligands from the pathogenic S. aureus strain are not the cause for the inadequate mammary immune response elicited by this pathogen, and the pathogen causing subclinical mastitis impairs NF-kappaB activation in MEC thereby severely weakening the immune response in the udder.
Journal ArticleDOI
Escherichia coli, but not Staphylococcus aureus triggers an early increased expression of factors contributing to the innate immune defense in the udder of the cow
Wolfram Petzl,Holm Zerbe,Juliane Günther,Wei Yang,Hans-Martin Seyfert,Gerd Nürnberg,Hans-Joachim Schuberth +6 more
TL;DR: Using the established mastitis model, the data clearly demonstrate a pathogen-dependent difference in the time kinetics of induced pathogen receptors and defense molecules.
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Comparative Kinetics of Escherichia coli- and Staphylococcus aureus-Specific Activation of Key Immune Pathways in Mammary Epithelial Cells Demonstrates That S. aureus Elicits a Delayed Response Dominated by Interleukin-6 (IL-6) but Not by IL-1A or Tumor Necrosis Factor Alpha
Juliane Günther,Kathrin Esch,Norbert Poschadel,Wolfram Petzl,Holm Zerbe,Simone Mitterhuemer,Helmut Blum,Hans-Martin Seyfert +7 more
TL;DR: The kinetics and extents of global changes in the transcriptome of primary bovine mammary epithelial cells (MEC) after challenging them with heat-inactivated preparations of E. coli or S. aureus are profiled to suggest that S.Aureus subverts the MyD88-dependent activation of immune gene expression in MEC.
Journal ArticleDOI
Escherichia coli infection induces distinct local and systemic transcriptome responses in the mammary gland
Simone Mitterhuemer,Wolfram Petzl,Stefan Krebs,Daniel Mehne,Andrea Klanner,Eckhard Wolf,Holm Zerbe,Helmut Blum +7 more
TL;DR: The discovery and holistic analysis of an extensive systemic reaction in the mammary gland significantly expands the knowledge of host-pathogen interactions in mastitis which may be relevant for the development of novel therapies and for genetic selection towards mastitis resistance.