Wyne P. Lee

TL;DR: NEDD4-binding protein 1 (N4BP1) is identified as a suppressor of cytokine production that is cleaved and inactivated by caspase-8, which provides insight into the mechanisms underlying the immunodeficiency caused by mutations in FADD and casp enzyme-8.

TL;DR: The present report substantiates the potential of rhTGF-beta 1 and its carrier for treatment of bone defects and suggests the growth factor was stable in this formulation before and after in vitro release.

TL;DR: It is shown that IL-20 subfamily cytokines are upregulated during normal wound healing, and IL-22 uniquely induced genes involved in reepithelialization, tissue remodeling and innate host defense mechanisms from wounded skin are involved in DFU.

TL;DR: To determine whether a combination of B cell depletion and BAFF blockade is more effective than monotherapy in treating models of spontaneous or accelerated systemic lupus erythematosus (SLE) in (NZB × NZW)F1 mice, data are presented on mice treated with either NZB or NZW mice with SLE.

TL;DR: A conserved and critical role for TPL2 is described in mediating the effector functions of neutrophils through the activation of the p38 MAPK signaling pathway, a drug target that activates not only MEK1/2-dependent but also MEK3/6-dependent signaling to promote inflammatory responses.