K
Kate Senger
Researcher at Genentech
Publications - 31
Citations - 1844
Kate Senger is an academic researcher from Genentech. The author has contributed to research in topics: Enhancer & Immunoglobulin class switching. The author has an hindex of 19, co-authored 29 publications receiving 1599 citations. Previous affiliations of Kate Senger include Columbia University & University of North Carolina at Chapel Hill.
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Journal ArticleDOI
Acetylation of HMG I(Y) by CBP Turns off IFNβ Expression by Disrupting the Enhanceosome
TL;DR: It is demonstrated that acetylation of HMG I(Y) by CBP is essential for turning off IFN beta gene expression, and the acetyltransferase activities of CBP and P/CAF modulate both the strength of the transcriptional response and the kinetics of virus-dependent activation of the IFN Beta gene.
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Computational models for neurogenic gene expression in the Drosophila embryo.
TL;DR: It is proposed that binding site occupancy is the key rate-limiting step for establishing localized patterns of gene expression in the early Drosophila embryo.
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Immunity Regulatory DNAs Share Common Organizational Features in Drosophila
Kate Senger,Grant W Armstrong,William J Rowell,Jennifer M. Kwan,Michele Markstein,Michael Levine +5 more
TL;DR: Evidence that REL-GATA synergy plays a pervasive role in the immune response is presented and SELEX assays suggest that immunity regulatory DNAs contain constrained organizational features, which may be a general property of eukaryotic enhancers.
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Mechanism by which the ifn-beta enhanceosome activates transcription
TL;DR: It is demonstrated that in contrast to previous findings by using simple synthetic promoters or activators, the natural IFN-beta enhanceosome activates transcription by causing a dramatic increase of the rate by which preinitiation complexes assemble at the promoter.
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The Indian cobra reference genome and transcriptome enables comprehensive identification of venom toxins.
Kushal Suryamohan,Sajesh Puthenpurackal Krishnankutty,Joseph Guillory,Matthew Jevit,Markus S. Schröder,Meng Wu,Boney Kuriakose,Oommen K. Mathew,Rajadurai Chinnasamy Perumal,Ivan Koludarov,Leonard D. Goldstein,Kate Senger,Mandumpala Davis Dixon,Dinesh Velayutham,Derek Vargas,Subhra Chaudhuri,Megha Muraleedharan,Ridhi Goel,Ying Jiun J. Chen,Aakrosh Ratan,Peter Liu,Brendan Faherty,Guillermo de la Rosa,Hiroki Shibata,Miriam Baca,Meredith Sagolla,James Ziai,Gus A. Wright,Domagoj Vucic,Sangeetha Mohan,Aju Antony,Jeremy Stinson,Donald S. Kirkpatrick,Rami N. Hannoush,Steffen Durinck,Zora Modrusan,Eric Stawiski,Kristen Wiley,Terje Raudsepp,R. Manjunatha Kini,Arun Zachariah,Somasekar Seshagiri +41 more
TL;DR: The genome of Naja naja, the Indian cobra, a highly venomous, medically important snake, is reported, which could serve as a reference for snake genomes, support evolutionary studies and enable venom-driven drug discovery.