Wyne P. Lee

TL;DR: The protein tyrosine phosphatase PEP, associated with lupus and other autoimmune diseases, inhibits IFN-α receptor signaling in mice, and PEP-deficient hematopoietic progenitors demonstrate increased IFNAR signaling,IFN-inducible gene expression and proliferation.

TL;DR: Departure of hCRTh2+ basophils, eosinophil, ILC2, and Th2 cells with h19A2 h CRTh2-specific antibodies may be a novel and more efficacious treatment for asthma.

TL;DR: A system wherein human antigen-specific antibody–secreting plasmablasts can be enriched in vivo, in a severe combined immunodeficient (SCID)/beige mouse host, generating four broadly reactive anti–influenza A antibodies is developed.

TL;DR: The profound effect of TGF-β on disease progression in EAN, a T-cell-mediated process, is consistent with a direct effect of this growth factor on T lymphocytes.

TL;DR: The data show that local inhibition of Jak1 in the lung can suppress lung inflammation without systemic Jak inhibition in rodents, suggesting that this strategy might be effective for treating asthma.