Wyne P. Lee

TL;DR: Autophagy is implicate as a novel therapeutic target for GRN-associated NCL and FTD and highlighted the emerging theme of defective autophagy in the broader FTD/amyotrophic lateral sclerosis spectrum of neurodegenerative disease.

TL;DR: Inhibition of RIP1 reduced collagen antibody-induced arthritis, and prevented skin inflammation caused by mutation of Sharpin, or colitis caused by deletion of Nemo from intestinal epithelial cells, but its relevance to tumor progression and metastases is questioned.

TL;DR: It is shown that a critical output of Ras signaling in AT2 cells is inactivation of the ubiquitin ligase COP1, resulting in stabilization of the transcription factor ETV5, which is essential to maintain AT2 cell identity.

TL;DR: It is shown that experimental lupus in NZB/W F1 mice can be treated with a highly selective and potent NIK small molecule inhibitor, which results in improved survival, reduced renal pathology, and lower proteinuria scores, suggesting that NIK inhibition is a potential therapeutic approach for SLE.

TL;DR: A potential therapeutic role for rhTGF‐β1 is suggested in hard tissue repair after a single application of recombinant human transforming growth factor β1 adjacent to cartilage was found to induce bone formation in rabbit ear full‐thickness skin wounds.