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X. Josette Chen
Researcher at University of Toronto
Publications - 24
Citations - 1621
X. Josette Chen is an academic researcher from University of Toronto. The author has contributed to research in topics: Magnetic resonance imaging & Hyperpolarization (physics). The author has an hindex of 17, co-authored 24 publications receiving 1548 citations. Previous affiliations of X. Josette Chen include Duke University & Hospital for Sick Children.
Papers
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Journal ArticleDOI
MRI of the lungs using hyperpolarized noble gases.
Harald E. Möller,X. Josette Chen,Brian Saam,Klaus D. Hagspiel,G. Allan Johnson,Talissa A. Altes,Eduard E. de Lange,Hans-Ulrich Kauczor +7 more
TL;DR: The physics underlying the optical pumping process, imaging strategies coping with the nonequilibrium polarization, and effects of the alveolar microstructure on relaxation and diffusion of the noble gases are outlined.
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Tbx5-dependent rheostatic control of cardiac gene expression and morphogenesis.
Alessandro D. Mori,Yonghong Zhu,Ilyas Vahora,Brian J. Nieman,Kazuko Koshiba-Takeuchi,Lorinda Davidson,Anne Pizard,Jonathan G. Seidman,Christine E. Seidman,Christine E. Seidman,X. Josette Chen,R. Mark Henkelman,Benoit G. Bruneau +12 more
TL;DR: In this paper, the T-box transcription factor gene TBX5 was found to cause Holt-Oram syndrome (HOS), an inherited human disease characterized by upper limb malformations and congenital heart defects (CHDs) of variable severity.
Journal ArticleDOI
Detection of emphysema in rat lungs by using magnetic resonance measurements of 3He diffusion.
X. Josette Chen,Laurence W. Hedlund,Harald E. Möller,Mark S. Chawla,Robert R. Maronpot,G. Allan Johnson +5 more
TL;DR: The results indicate that measurement of the hyperpolarized (3)He ADC can be a valuable research tool and has potential application in the clinical setting, and the data show that the ADC is significantly larger in elastase-treated rats, indicating alveolar expansion.
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Comprehensive transthoracic cardiac imaging in mice using ultrasound biomicroscopy with anatomical confirmation by magnetic resonance imaging
Yu-Qing Zhou,F. Stuart Foster,F. Stuart Foster,Brian J. Nieman,Lorinda Davidson,X. Josette Chen,R. Mark Henkelman,R. Mark Henkelman +7 more
TL;DR: The methodologies and baseline measurements of inbred mice provide a useful guide for investigators applying the high-frequency ultrasound imaging to mouse cardiac phenotyping.
Journal ArticleDOI
Neuroanatomical differences between mouse strains as shown by high-resolution 3D MRI.
X. Josette Chen,Natasa Kovacevic,Nancy J. Lobaugh,John G. Sled,R. Mark Henkelman,Jeffrey T. Henderson +5 more
TL;DR: 3D neuroanatomy of three strains of mice (129S1/SvImJ, C57/Bl6, and CD1) is significantly different from one another, and significant local deviations in volume and displacement between the two inbred strains are assessed.