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Xi He
Researcher at University of California, San Diego
Publications - 7
Citations - 1617
Xi He is an academic researcher from University of California, San Diego. The author has contributed to research in topics: POU domain & Transcription factor. The author has an hindex of 7, co-authored 7 publications receiving 1602 citations.
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Journal ArticleDOI
Expression of a large family of POU-domain regulatory genes in mammalian brain development.
Xi He,Maurice N. Treacy,Donna M. Simmons,Donna M. Simmons,Holly A. Ingraham,Holly A. Ingraham,Larry W. Swanson,Larry W. Swanson,Michael G. Rosenfeld,Michael G. Rosenfeld +9 more
TL;DR: The identification of multiple new members of a large family of POU-domain genes expressed in adult brain are reported, and it is documented that all the known mammalian Pou- domain genes, including Pit-1 and Oct-2, are expressed widely in the developing nervous system.
Journal ArticleDOI
I-POU: a POU-domain protein that inhibits neuron-specific gene activation.
TL;DR: The inhibition by I-POU provides a potential strategy by which the activation of genes in development is controlled by a homeodomain-containing protein that does not bind DNA.
Journal ArticleDOI
Mechanisms of complex transcriptional regulation: implications for brain development.
Xi He,Michael G. Rosenfeld +1 more
TL;DR: Combinatorial codes for highly complex and yet highly organized patterns of gene expression likely to underlie the determination of diversity of neuronal phenotypes will greatly facilitate the study of neural development and function.
Journal ArticleDOI
Brain 4: a novel mammalian POU domain transcription factor exhibiting restricted brain-specific expression.
TL;DR: Brn‐4 was shown to bind to DNA sequences containing the octamer motif and to trans‐activate promoters containing this DNA binding motif, based on the actions of a unique N‐terminal information, indicating that certain POU domain genes potentially exert their primary functions widely during early neural development, and in a very limited set of neurons in the mature brain.
Journal ArticleDOI
Tst-1, a member of the POU domain gene family, binds the promoter of the gene encoding the cell surface adhesion molecule P0.
Xi He,R. Gerrero,Donna M. Simmons,R. E. Park,Chijen R. Lin,Larry W. Swanson,Michael G. Rosenfeld +6 more
TL;DR: Bacterially expressed Tst-1 binds specifically to the promoter of the gene encoding myelin protein P0, a Schwann cell surface adhesion molecule, and can specifically repress the P0 promoter in cotransfection assays.