Xi Lan

TL;DR: Key studies on modulators of microglial activation and polarization after ICH are summarized, including M1-like and M2-like microglia phenotype markers, transcription factors and key signalling pathways, and the evidence that therapeutic approaches aimed at modulating microglian function might mitigate ICH injury and improve brain repair is presented.

TL;DR: It is found that administration of ferrostatin-1, a specific inhibitor of ferroptosis, prevented neuronal death and reduced iron deposition induced by hemoglobin in organotypic hippocampal slice cultures (OHSCs) and human induced pluripotent stem cell-derived neurons better than any inhibitor alone.

TL;DR: This review summarizes current research on ferroptosis, its underlying mechanisms, and its role in the progression of different neurologic diseases and provides valuable information regarding treatment and prevention of these devastating diseases.

TL;DR: Inhibition of the TLR4 signaling pathway and reduction in M1-like microglial polarization might be the major mechanism by which pinocembrin protects hemorrhagic brain in ICH and other acute brain injuries.

TL;DR: Pinocembrin has potential as a drug to treat ischemic stroke and other clinical conditions and its pharmacologic characteristics are summarized and its mechanisms of action are discussed.