Qian Li

TL;DR: It is found that LSD1 is downregulated in breast carcinomas and that its level of expression is negatively correlated with that of TGFbeta1, which provides a molecular basis for the interplay of histone demethylation and deacetylation in chromatin remodeling.

TL;DR: Key studies on modulators of microglial activation and polarization after ICH are summarized, including M1-like and M2-like microglia phenotype markers, transcription factors and key signalling pathways, and the evidence that therapeutic approaches aimed at modulating microglian function might mitigate ICH injury and improve brain repair is presented.

TL;DR: It is found that administration of ferrostatin-1, a specific inhibitor of ferroptosis, prevented neuronal death and reduced iron deposition induced by hemoglobin in organotypic hippocampal slice cultures (OHSCs) and human induced pluripotent stem cell-derived neurons better than any inhibitor alone.

TL;DR: This review summarizes current research on ferroptosis, its underlying mechanisms, and its role in the progression of different neurologic diseases and provides valuable information regarding treatment and prevention of these devastating diseases.

TL;DR: It is reported that SET8 is physically associated with TWIST, a master regulator of epithelial–mesenchymal transition (EMT), and the experiments revealed a novel role for SET8 in tumour invasion and metastasis and provide a molecular mechanism underlying TWIST‐promoted EMT, suggesting SET8 as a potential target for intervention of the metastasis of breast cancer.