X
Xianglin Shi
Researcher at Chinese Academy of Sciences
Publications - 69
Citations - 4467
Xianglin Shi is an academic researcher from Chinese Academy of Sciences. The author has contributed to research in topics: Radical & Spin trapping. The author has an hindex of 38, co-authored 69 publications receiving 4265 citations. Previous affiliations of Xianglin Shi include National Institutes of Health & The Graduate Center, CUNY.
Papers
More filters
Journal ArticleDOI
Role of PI3K/AKT/mTOR signaling in the cell cycle progression of human prostate cancer.
TL;DR: It is suggested that PI3K mediates G(1) cell cycle progression and cyclin expression through the activation of AKT/mTOR/p70(S6K) signaling pathway in the prostate cancer cells.
Journal ArticleDOI
Antioxidant behaviour of caffeine: efficient scavenging of hydroxyl radicals.
TL;DR: ESR measurements provide evidence that a caffeine-derived oxygen-centred radical is formed in the reaction of caffeine with .OH and suggest a biochemical basis for the understanding of the reported anticarcinogenic properties of caffeine and related methylxanthine compounds.
Journal ArticleDOI
Apigenin inhibits tumor angiogenesis through decreasing HIF-1α and VEGF expression
Jing Fang,Qiong Zhou,Ling-Zhi Liu,Chang Xia,Xiaowen Hu,Xianglin Shi,Bing-Hua Jiang,Bing-Hua Jiang +7 more
TL;DR: It is demonstrated that apigenin significantly inhibited tumor angiogenesis in vivo, by using both the chicken chorioallantoic membrane and Matrigel plug assays, and the inhibition of tumorAngiogenesis was associated with the decrease of HIF-1 and VEGF in tumor tissues.
Journal ArticleDOI
Reactive oxygen species regulate epidermal growth factor-induced vascular endothelial growth factor and hypoxia-inducible factor-1α expression through activation of AKT and P70S6K1 in human ovarian cancer cells
Ling-Zhi Liu,Xiaowen Hu,Chang Xia,Jie He,Qiong Zhou,Xianglin Shi,Jing Fang,Bing-Hua Jiang,Bing-Hua Jiang +8 more
TL;DR: A novel mechanism of EGF-induced VEGF and HIF-1α expression through production of H2O2 and activation of AKT and p70S6K1 in human ovarian cancer cells is demonstrated.
Journal ArticleDOI
Carcinogenic effect of nickel compounds.
TL;DR: The present review summarizes the current knowledge on the molecular mechanisms of nickel carcinogenesis, with special emphasis on the role of nickel induced reactive oxygen species (ROS) and signal transduction pathways.