Xiao-Di Zhang

TL;DR: It is reported that lentivirus-based transgenic cynomolgus monkeys (Macaca fascicularis) expressing human MeCP2 in the brain exhibit autism-like behaviours and show germline transmission of the transgene, indicating the feasibility and reliability of using genetically engineered non-human primates to study brain disorders.

TL;DR: This work reports a new form of plasticity in neonatal mice, where early sensory experience cross-modally regulates development of all sensory cortices via oxytocin signaling, and identifies a new function for Oxytocin in promotingCross-modal, experience-dependent cortical development.

TL;DR: It is shown that within 2 hr of systemic inflammation, PDGFRβ mural cells of blood vessels rapidly secrete chemokine CCL2, which in turn increases total neuronal excitability by promoting excitatory synaptic transmission in glutamatergic neurons of multiple brain regions.

TL;DR: This is the first identification and characterization of Chinese Han patients with MECP2-containing duplications, and based on the published literature, M ECP2 is the most autism-associated gene among the identified CNVs.

TL;DR: In this article, the effects of the neuropeptide oxytocin on synaptic transmission in L2/3 pyramidal neurons of the barrel field of the primary somatosensory cortex (S1BF) were examined.