X
Xiao Sang
Researcher at Chinese Academy of Sciences
Publications - 4
Citations - 322
Xiao Sang is an academic researcher from Chinese Academy of Sciences. The author has contributed to research in topics: Transgene & Gene targeting. The author has an hindex of 4, co-authored 4 publications receiving 251 citations. Previous affiliations of Xiao Sang include Boston Children's Hospital.
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Journal ArticleDOI
Autism-like behaviours and germline transmission in transgenic monkeys overexpressing MeCP2
Zhen Liu,Xiao Li,Jun-Tao Zhang,Yijun Cai,Tian-Lin Cheng,Cheng Cheng,Yan Wang,Chen-Chen Zhang,Yanhong Nie,Zhi-Fang Chen,Wen-Jie Bian,Ling Zhang,Jianqiu Xiao,Bin Lu,Yuefang Zhang,Xiao-Di Zhang,Xiao Sang,Jia-Jia Wu,Xiu Xu,Zhi-Qi Xiong,Feng Zhang,Xiang Yu,Neng Gong,Wenhao Zhou,Qiang Sun,Zilong Qiu +25 more
TL;DR: It is reported that lentivirus-based transgenic cynomolgus monkeys (Macaca fascicularis) expressing human MeCP2 in the brain exhibit autism-like behaviours and show germline transmission of the transgene, indicating the feasibility and reliability of using genetically engineered non-human primates to study brain disorders.
Journal ArticleDOI
Generation of a monkey with MECP2 mutations by TALEN-based gene targeting
Zhen Liu,Xue Zhou,Ying Zhu,Zhi-Fang Chen,Bin Yu,Bin Yu,Yan Wang,Chen-Chen Zhang,Yanhong Nie,Xiao Sang,Xiao Sang,Yijun Cai,Yuefang Zhang,Chen Zhang,Wenhao Zhou,Qiang Sun,Zilong Qiu +16 more
TL;DR: The generation of a cynomolgus monkey carrying MECP2 mutations using transcription activator-like effector nucleases (TALENs)-mediated gene targeting demonstrates the feasibility of introducing genetic mutations in non-human primates by site-specific gene-editing methods.
Journal ArticleDOI
Sleep and circadian abnormalities precede cognitive deficits in R521C FUS knockin rats.
Tao Zhang,Xin Jiang,Min Xu,Haifang Wang,Xiao Sang,Meiling Qin,Puhua Bao,Ruiqi Wang,Chen-Chen Zhang,Hui-Ping Lu,Yuzhuo Li,Jin Ren,Hung-Chun Chang,Jun Yan,Qiang Sun,Jin Xu +15 more
TL;DR: A rodent model expressing physiological level of a pathogenic mutant FUS is established and a new role of FUS in sleep and circadian regulation is revealed, and it is demonstrated that functional change in FUS could cause sleep-wake and circadian disturbance as early symptoms.
Journal ArticleDOI
Reduction of HIP2 expression causes motor function impairment and increased vulnerability to dopaminergic degeneration in Parkinson's disease models
Jinlin Su,Pei Huang,Meiling Qin,Qingqing Lu,Xiao Sang,Yijun Cai,Ying Wang,Fubing Liu,Rong Wu,Xiaoping Wang,Xiaoxing Jiang,Jian Wang,Qiang Sun,Sheng-Di Chen,Jin Xu +14 more
TL;DR: In vivo studies have indicated HIP2 insufficiency as a contributing factor for PD, and functionally validated blood HIP2 as a useful and reversible biomarker for PD.