J
Jianqiu Xiao
Researcher at Fudan University
Publications - 8
Citations - 291
Jianqiu Xiao is an academic researcher from Fudan University. The author has contributed to research in topics: Medicine & Copy-number variation. The author has an hindex of 5, co-authored 5 publications receiving 229 citations.
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Journal ArticleDOI
Autism-like behaviours and germline transmission in transgenic monkeys overexpressing MeCP2
Zhen Liu,Xiao Li,Jun-Tao Zhang,Yijun Cai,Tian-Lin Cheng,Cheng Cheng,Yan Wang,Chen-Chen Zhang,Yanhong Nie,Zhi-Fang Chen,Wen-Jie Bian,Ling Zhang,Jianqiu Xiao,Bin Lu,Yuefang Zhang,Xiao-Di Zhang,Xiao Sang,Jia-Jia Wu,Xiu Xu,Zhi-Qi Xiong,Feng Zhang,Xiang Yu,Neng Gong,Wenhao Zhou,Qiang Sun,Zilong Qiu +25 more
TL;DR: It is reported that lentivirus-based transgenic cynomolgus monkeys (Macaca fascicularis) expressing human MeCP2 in the brain exhibit autism-like behaviours and show germline transmission of the transgene, indicating the feasibility and reliability of using genetically engineered non-human primates to study brain disorders.
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Efficient CNV breakpoint analysis reveals unexpected structural complexity and correlation of dosage-sensitive genes with clinical severity in genomic disorders.
Ling Zhang,Jingmin Wang,Cheng Zhang,Dongxiao Li,Claudia M.B. Carvalho,Haoran Ji,Jianqiu Xiao,Ye Wu,Weichen Zhou,Hongyan Wang,Li Jin,Yang Luo,Xiru Wu,James R. Lupski,James R. Lupski,Feng Zhang,Yuwu Jiang +16 more
TL;DR: These sequence‐based structures of PMD‐associated CNVs further support the role of DNA replicative mechanisms in CNV mutagenesis, and facilitate genotype‐phenotype correlation studies.
Journal ArticleDOI
Elevated microRNA-520d-5p in the serum of patients with Parkinson's disease, possibly through regulation of cereloplasmin expression.
Lirong Jin,Wenbin Wan,Lingyan Wang,Changpeng Wang,Jianqiu Xiao,Feng Zhang,Jue Zhao,Jian Wang,Cheng Zhan,Chunjiu Zhong +9 more
TL;DR: In vitro experiments showed that miR-520d-5p reduced ceruloplasmin gene expression in the U251 astrocyte cell line, and the data suggest thatmiR- 520d- 5p may be a potential regulator of cerulplasmin genes expression in vitro.
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Single-nucleotide polymorphisms and haplotypes of non-coding area in the CP gene are correlated with Parkinson's disease.
TL;DR: It is suggested that common genetic variants of CP are associated with PD and further investigation is needed to explore their functions in PD.
Journal ArticleDOI
Rearrangement structure-independent strategy of CNV breakpoint analysis
Jianqiu Xiao,Ling Zhang,Jingmin Wang,Yuwu Jiang,Lirong Jin,Jianqi Lu,Li Jin,Chunjiu Zhong,Xiangmin Xu,Feng Zhang +9 more
TL;DR: A new method of capture and breakpoint approaching sequencing (CBAS) to efficiently obtain CNV breakpoint sequences and mapping insertional events as well was developed and revealed unexpected CNV complexity involving long-range DNA rearrangement.