Q
Qiang Sun
Researcher at Chinese Academy of Sciences
Publications - 6
Citations - 701
Qiang Sun is an academic researcher from Chinese Academy of Sciences. The author has contributed to research in topics: Transgene & Embryonic stem cell. The author has an hindex of 6, co-authored 6 publications receiving 541 citations. Previous affiliations of Qiang Sun include East China Normal University.
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Journal ArticleDOI
Autism-like behaviours and germline transmission in transgenic monkeys overexpressing MeCP2
Zhen Liu,Xiao Li,Jun-Tao Zhang,Yijun Cai,Tian-Lin Cheng,Cheng Cheng,Yan Wang,Chen-Chen Zhang,Yanhong Nie,Zhi-Fang Chen,Wen-Jie Bian,Ling Zhang,Jianqiu Xiao,Bin Lu,Yuefang Zhang,Xiao-Di Zhang,Xiao Sang,Jia-Jia Wu,Xiu Xu,Zhi-Qi Xiong,Feng Zhang,Xiang Yu,Neng Gong,Wenhao Zhou,Qiang Sun,Zilong Qiu +25 more
TL;DR: It is reported that lentivirus-based transgenic cynomolgus monkeys (Macaca fascicularis) expressing human MeCP2 in the brain exhibit autism-like behaviours and show germline transmission of the transgene, indicating the feasibility and reliability of using genetically engineered non-human primates to study brain disorders.
Journal ArticleDOI
Cloning of Macaque Monkeys by Somatic Cell Nuclear Transfer.
Zhen Liu,Yijun Cai,Yan Yan Wang,Yanhong Nie,Chen-Chen Zhang,Yuting Xu,Xiaotong Zhang,Yong Lu,Zhanyang Wang,Mu-ming Poo,Qiang Sun +10 more
TL;DR: It is found that injection of H3K9me3 demethylase Kdm4d mRNA and treatment with histone deacetylase inhibitor trichostatin A at one-cell stage following SCNT greatly improved blastocyst development and pregnancy rate of transplanted SCNT embryos in surrogate monkeys.
Journal ArticleDOI
Generation of haploid embryonic stem cells from Macaca fascicularis monkey parthenotes
Hui Yang,Zhen Liu,Yu Ma,Cuiqing Zhong,Qi Yin,Chikai Zhou,Chikai Zhou,Linyu Shi,Yijun Cai,Hanzhi Zhao,Hui Wang,Fan Tang,Yan Wang,Chen-Chen Zhang,Xinyuan Liu,Dongmei Lai,Ying Jin,Qiang Sun,Jinsong Li +18 more
TL;DR: The derivation of haESCs from parthenogenetic blastocysts of Macaca fascicularis monkeys is reported, demonstrating that PG-haESCs can be generated from monkeys, providing an ideal tool for genetic analyses in primates.
Journal ArticleDOI
Loss of FMRP Impaired Hippocampal Long-Term Plasticity and Spatial Learning in Rats
Yonglu Tian,Chaojuan Yang,Shujiang Shang,Yijun Cai,Xiaofei Deng,Jian Zhang,Feng Shao,Desheng Zhu,Yunbo Liu,Guiquan Chen,Jing Liang,Qiang Sun,Zilong Qiu,Chen Zhang,Chen Zhang +14 more
TL;DR: The results demonstrate that deletion of the Fmr1 gene in rats specifically impairs long-term synaptic plasticity and hippocampus-dependent learning in a manner resembling the key symptoms of FXS.