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Xiao-Fang Che
Researcher at Tokyo Medical University
Publications - 45
Citations - 1276
Xiao-Fang Che is an academic researcher from Tokyo Medical University. The author has contributed to research in topics: Apoptosis & Programmed cell death. The author has an hindex of 23, co-authored 44 publications receiving 1181 citations. Previous affiliations of Xiao-Fang Che include Kagoshima University.
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Journal ArticleDOI
Combined treatment with bortezomib plus bafilomycin A1 enhances the cytocidal effect and induces endoplasmic reticulum stress in U266 myeloma cells: Crosstalk among proteasome, autophagy-lysosome and ER stress
Tomohiro Kawaguchi,Keisuke Miyazawa,Shota Moriya,Tadashi Ohtomo,Xiao-Fang Che,Munekazu Naito,Masahiro Itoh,Akio Tomoda +7 more
TL;DR: Combined treatment with BZ and bafilomycin A1 (BAF), which is a specific inhibitor of vacuolar-ATPase and is used as an autophagy inhibitor at the late stage, resulted in synergistic cytotoxicity, compared with that by either BZ or BAF alone.
Journal ArticleDOI
Macrolide antibiotics block autophagy flux and sensitize to bortezomib via endoplasmic reticulum stress-mediated CHOP induction in myeloma cells
Shota Moriya,Xiao-Fang Che,Seiichiro Komatsu,Akihisa Abe,Tomohiro Kawaguchi,Akihiko Gotoh,Masato Inazu,Akio Tomoda,Keisuke Miyazawa +8 more
TL;DR: Simultaneously targeting two major intracellular protein degradation systems such as the ubiquitin-proteasome system by BZ and the autophagy-lysosomes system by a macrolide antibiotic enhances ER stress-mediated apoptosis in MM cells.
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Reversal of the resistance to STI571 in human chronic myelogenous leukemia K562 cells
Motoi Mukai,Xiao-Fang Che,Tatsuhiko Furukawa,Tomoyuki Sumizawa,Shunji Aoki,Xioa Qin Ren,Misako Haraguchi,Yoshikazu Sugimoto,Motomasa Kobayashi,Hideo Takamatsu,Shin-ichi Akiyama +10 more
TL;DR: It is suggested that STI571 is a substrate for P‐gp, but is less efficiently transported by P‐ gp than VCR, and STi571 is not a substrateFor MRP1.
Journal ArticleDOI
Reduced Frequency, Diversity, and Function of Human T Cell Leukemia Virus Type 1-Specific CD8+ T Cell in Adult T Cell Leukemia Patients
Tomohiro Kozako,Naomichi Arima,Shingo Toji,Izumi Masamoto,Masaki Akimoto,Heiichiro Hamada,Xiao-Fang Che,Hiroshi Fujiwara,Kakushi Matsushita,Masahito Tokunaga,Koichi Haraguchi,Kimiharu Uozumi,Susumu Suzuki,Toshiro Takezaki,Shunro Sonoda +14 more
TL;DR: Results suggest that decreased frequency, diversity, and function of anti-HTLV-1 Tax CD8+ T cell clones may be one of the risks of ATL development.
Journal ArticleDOI
Copper-Transporting P-Type ATPase, ATP7A, Confers Multidrug Resistance and Its Expression Is Related to Resistance to SN-38 in Clinical Colon Cancer
Satsuki Owatari,Satoshi Akune,Masaharu Komatsu,Ryuji Ikeda,Stephen D. Firth,Xiao-Fang Che,Masatatsu Yamamoto,Kazutake Tsujikawa,Masaki Kitazono,Takashi Ishizawa,Toru Takeuchi,Takashi Aikou,Julian F.B. Mercer,Shin-ichi Akiyama,Tatsuhiko Furukawa +14 more
TL;DR: It is found that ATP7A transfection of Chinese hamster ovary cells and fibroblasts isolated from Menkes disease patients enhanced resistance not only to CDDP but also to various anticancer drugs, and the trans-Golgi network has an important role of ATP 7A-related drug resistance.