Xiao-lin Yu

TL;DR: Results indicated that rutin is a promising agent for AD treatment because of its antioxidant, anti-inflammatory, and reducing Aβ oligomer activities.

TL;DR: In vitro results indicate that rutin is a promising natural product for protecting neuronal cells from amylin-induced neurotoxicity and oxidative stress, and r Rutin administration could be a feasible therapeutic strategy for preventing AD development and protecting the aging brain or slowing neurodegenerative processes.

TL;DR: Evidence that RV treatment alleviated motor and cognitive deficits in the A53T α-synuclein mouse model of PD in a dose-dependent manner and the beneficial effects of RV against PD resulted from inhibiting α- Synuclein aggregation and cytotoxicity, lowering the levels of total α- synuclein and oligomers, reducing neuroinflammation and oxidative stress.

TL;DR: In this article, the B cell epitopes on the spike (S), envelope (E), membrane (M), and nucleocapsid (N) proteins of SARS-CoV-2 using structure-based approaches were validated by immunizing mice.

TL;DR: It is found that this peptide significantly improved spatial memory and reduced the amyloid plaque burden and soluble and insoluble Aβ levels and this multifunctional peptide has therapeutic potential for an Aβ-targeted treatment of AD.