Xiao Na Ge

TL;DR: It is shown that ORMDL3 regulates eosinophil trafficking, recruitment and degranulation, further elucidating a role for this molecule in allergic asthma and potentially other eOSinophilic disorders.

TL;DR: The results suggest that myocardin gene, as a marker of smooth muscle cell differentiation, was expressed in the pulmonary vessels in hypoxia‐induced PH rats, which could be downregulated by Sildenafil treatment, as well as in hypoxic cultured endothelial cells.

TL;DR: It is demonstrated that Gal-3 is an important lectin that promotes airway remodeling via airway recruitment of inflammatory cells, specifically eosinophils, and the development of a Th2 phenotype as well as increased expression of eOSinophil-specific chemokines and profibrogenic and angiogenic mediators.

TL;DR: Endothelial-expressed HS plays an important role in allergic airway inflammation through the regulation of recruitment of inflammatory cells to the airways by mediating interaction of leukocytes with the vascular endothelium and may also participate by sequestering and modulating the activity of allergic asthma-relevant mediators such as IL-5, IL-2, and TGF-β1.

TL;DR: It is suggested that Gal-1 can limit eosinophil recruitment to allergic airways and suppresses airway inflammation by inhibiting cell migration and promoting eos inophil apoptosis.