Xiao-Yong Li

TL;DR: It is suggested that most animal transcription factors will be found to show a similar broad overlapping pattern of binding in vivo, with specificity achieved by modulating the amount, rather than the identity, of bound factor.

TL;DR: Thousands of regions bound by zinc-finger protein Zelda are identified in cycle 8 embryos, suggesting that ZLD is not only required for the earliest wave of transcription but also plays a major role in activating the genome at the MZT.

TL;DR: Genome-wide comparison of transcription factor binding between related Drosophila species highlights how sequence changes affect the biochemical events that underlie animal development.

TL;DR: Early histone acetylation is strongly associated with regions that have been shown to be bound in early embryos by the maternally deposited transcription factor Zelda, suggesting that Zelda triggers a cascade of events, including the accumulation of specific histone modifications, that plays a role in the subsequent activation of these sequences.

TL;DR: It is proposed that localized modulation of transcription factor on rates via clustering provides a general mechanism to facilitate binding to low-affinity targets and that this may be a prevalent feature of other developmental transcription factors.