X
Xiaojing Chu
Researcher at Chinese Academy of Sciences
Publications - 15
Citations - 405
Xiaojing Chu is an academic researcher from Chinese Academy of Sciences. The author has contributed to research in topics: Receptor & G protein-coupled receptor. The author has an hindex of 3, co-authored 6 publications receiving 68 citations.
Papers
More filters
Journal ArticleDOI
Structural basis of Gs and Gi recognition by the human glucagon receptor
Anna Qiao,Shuo Han,Xinmei Li,Zhixin Li,Peishen Zhao,Antao Dai,Rulve Chang,Linhua Tai,Qiuxiang Tan,Xiaojing Chu,Limin Ma,Thor Seneca Thorsen,Steffen Reedtz-Runge,Dehua Yang,Ming-Wei Wang,Patrick M. Sexton,Patrick M. Sexton,Denise Wootten,Denise Wootten,Fei Sun,Qiang Zhao,Beili Wu +21 more
TL;DR: Structures of a G protein–coupled receptor bound to two different G proteins reveal molecular details that govern G protein selectivity.
Journal ArticleDOI
Structural basis of tethered agonism of the adhesion GPCRs ADGRD1 and ADGRF1
Xiangli Qu,N. Qiu,Mu Wang,Bingjie Zhang,J. Du,Zhiwei Zhong,Wei Xu,Xiaojing Chu,Limin Ma,Cuiying Yi,Shuo Han,Wenqing Shui,Qiang Zhao,Beili Wu +13 more
TL;DR: The G protein-bound structures of ADGRD1 and ADGRF1 are reported, which exhibit many unique features with regard to the tethered agonism and highlight the diversity and complexity of the signal transduction mechanisms of the aGPCRs.
Journal ArticleDOI
Structures of Gi-bound metabotropic glutamate receptors mGlu2 and mGlu4
Shuling Lin,Shuo Han,Xiaoqing Cai,Qiuxiang Tan,Kexiu Zhou,Kexiu Zhou,Dejian Wang,Xinwei Wang,Juan Du,Cuiying Yi,Xiaojing Chu,Antao Dai,Yan Zhou,Yan Chen,Yu Zhou,Hong Liu,Hong Liu,Jianfeng Liu,Dehua Yang,Ming-Wei Wang,Qiang Zhao,Beili Wu +21 more
TL;DR: In this article, the authors reported two structures of human metabotropic glutamate receptors (mGlu2 and mGlu4) bound to heterotrimeric Gi protein, which revealed a G-protein-binding site formed by three intracellular loops and helices.
Journal ArticleDOI
Structural basis of tethered agonism of the adhesion GPCRs ADGRD1 and ADGRF1
Xiangli Qu,N. Qiu,Mu Wang,Bingjie Zhang,J. Du,Zhiwei Zhong,Wei Xu,Xiaojing Chu,Limin Ma,Cuiying Yi,Shuo Han,Wenqing Shui,Qiang Zhao,Beili Wu +13 more
TL;DR: In this paper , the authors reported the G protein-bound structures of ADGRD1 and ADGRF1, which exhibit many unique features with regard to the tethered agonism.
Journal ArticleDOI
Structures of human mGlu2 and mGlu7 homo- and heterodimers
Juan Du,Dejian Wang,Hongcheng Fan,Chanjuan Xu,Linhua Tai,Shuling Lin,Shuo Han,Qiuxiang Tan,Xinwei Wang,Tuo Xu,Hui Zhang,Xiaojing Chu,Cuiying Yi,Liu Peng,Xiaomei Wang,Yu Zhou,Jean-Philippe Pin,Philippe Rondard,Hong Liu,Jianfeng Liu,Fei Sun,Beili Wu,Qiang Zhao +22 more
TL;DR: In this article, the structure and functional properties of the mGlu2-mGlu7 heterodimer were analyzed using four cryo-electron microscopy structures.