Wenqing Shui

TL;DR: The structure of the CB1-AM6538 complex reveals key features of the receptor and critical interactions for antagonist binding and provides insight into the binding mode of naturally occurring CB1 ligands, such as THC, and synthetic cannabinoids.

TL;DR: It is demonstrated that recombinant proteins expressed in mammalian cells can be site-specifically modified by using a genetically encoded aldehyde tag, and the technique was applied to site- specific modification of monoclonal antibodies, the fastest growing class of biopharmaceuticals.

TL;DR: A comprehensive overview of the field of G protein-coupled receptors (GPCRs) can be found in this article, where the authors provide a broader readership that shares some common interests in drug discovery.

TL;DR: Biological and mass spectroscopy results revealed that D-captopril can effectively inhibit the enzymatic activity of NDM-1 by binding to its active site with high binding affinity, and unique features concerning the primary sequence and structural conformation of the active site distinguish N DM-1 from other reported metallo-β-lactamases and implicate its role in wide spectrum drug resistance.

TL;DR: A proteomic analysis of the membrane fraction from latex bead-containing phagosomes isolated from macrophages suggests diverse functions of the phagosome and potential connections to secretory processes, toll-like receptor signaling, and autophagy.