P
Peishen Zhao
Researcher at Monash University
Publications - 47
Citations - 2021
Peishen Zhao is an academic researcher from Monash University. The author has contributed to research in topics: Receptor & G protein-coupled receptor. The author has an hindex of 18, co-authored 39 publications receiving 1432 citations. Previous affiliations of Peishen Zhao include University of Western Ontario & Australian Research Council.
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Journal ArticleDOI
Phase-plate cryo-EM structure of a biased agonist-bound human GLP-1 receptor-Gs complex.
Yi Lynn Liang,Maryam Khoshouei,Alisa Glukhova,Sebastian G.B. Furness,Peishen Zhao,Lachlan Clydesdale,Cassandra Koole,Tin T. Truong,David M. Thal,Saifei Lei,Mazdak Radjainia,Radostin Danev,Wolfgang Baumeister,Ming-Wei Wang,Ming-Wei Wang,Laurence J. Miller,Laurence J. Miller,Arthur Christopoulos,Patrick M. Sexton,Patrick M. Sexton,Denise Wootten +20 more
TL;DR: The structure of the human GLP-1 receptor in complex with the G protein-biased peptide exendin-P5 and a Gαs heterotrimer is described and provides insights into the molecular basis of biased agonism.
Journal ArticleDOI
Biased Signaling of Protease-Activated Receptors
TL;DR: A growing number of proteases have been identified that cleave PARs at divergent sites to activate distinct patterns of receptor signaling and trafficking, referred to as biased signaling, and can lead to unique patho-physiological outcomes.
Journal ArticleDOI
The Bile Acid Receptor TGR5 Activates the TRPA1 Channel to Induce Itch in Mice
Tina Marie Lieu,Gihan Jayaweera,Peishen Zhao,Daniel P. Poole,Daniel P. Poole,Dane D. Jensen,Megan S. Grace,Peter McIntyre,Romke Bron,Yvette M. Wilson,Matteus Krappitz,Silke Haerteis,Christoph Korbmacher,Martin Steinhoff,Romina Nassini,Serena Materazzi,Pierangelo Geppetti,Carlos U. Corvera,Nigel W. Bunnett,Nigel W. Bunnett +19 more
TL;DR: This work investigated whether the transient receptor potential ankyrin 1 (TRPA1) is involved in BA-evoked, TGR5-dependent pruritus in mice and found that antagonists of T GR5 and TRPA1, or inhibitors of the signaling mechanism by which Tgr5 activates TRpa1, might be developed for treatment of cholestaticPruritus.
Journal ArticleDOI
Cathepsin S Causes Inflammatory Pain via Biased Agonism of PAR2 and TRPV4
Peishen Zhao,Tina Marie Lieu,Nicholas Barlow,Matthew C. Metcalf,Nicholas A. Veldhuis,Dane D. Jensen,Martina Kocan,Silvia Sostegni,Silke Haerteis,Vera Baraznenok,Ian R. Henderson,Erik Lindström,Raquel Guerrero-Alba,Eduardo E. Valdez-Morales,Wolfgang Liedtke,Peter McIntyre,Stephen Vanner,Christoph Korbmacher,Nigel W. Bunnett,Nigel W. Bunnett +19 more
TL;DR: The results identify Cat-S as a biased agonist of PAR2 that causes PAR2- and TRPV4-dependent inflammation and pain and expand the role ofPAR2 as a mediator of protease-driven inflammatory pain.
Journal ArticleDOI
Neutrophil Elastase Activates Protease-activated Receptor-2 (PAR2) and Transient Receptor Potential Vanilloid 4 (TRPV4) to Cause Inflammation and Pain.
Peishen Zhao,Tina Marie Lieu,Nicholas Barlow,Silvia Sostegni,Silke Haerteis,Christoph Korbmacher,Wolfgang Liedtke,Nestor N. Jiménez-Vargas,Stephen Vanner,Nigel W. Bunnett,Nigel W. Bunnett +10 more
TL;DR: A novel mechanism of elastase-induced activation of TRPV4 is identified and the role of PAR2 is expanded as a mediator of protease-driven inflammation and pain.