Xiaomeng Ren

TL;DR: Lineage‐tracing studies demonstrated that Foxm1 increased EMT during radiation‐induced pulmonary fibrosis in vivo, and it was found that siRNA‐mediated inhibition ofFoxm1 prevented TGF‐β‐induced EMT in vitro.

TL;DR: FoxF1 is required for the formation of embryonic vasculature by regulating endothelial genes critical for vascular development and vascular endothelial growth factor signaling.

TL;DR: The findings implicate Foxf genes in atrioventricular septation, describe the molecular underpinnings of the genetic interaction between Hedgehog signaling and Tbx5, and establish a molecular model for the selection of the SHF gene regulatory network for cardiac septal defects are established.

TL;DR: expression of Foxm1 in respiratory epithelial cells is critical for lung cancer formation and TOPO-2α expression in vivo, suggesting that Foxm 1 is a promising target for anti-tumor therapy.

TL;DR: Expression of Foxm1 in macrophages is required for pulmonary inflammation, recruitment of macrophage into tumor sites and lung tumor growth, and decreased tumorigenesis was associated with diminished proliferation of tumor cells and decreased recruitment ofmacrophages during the early stages of tumor formation.