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Xiaoming He
Researcher at University of Maryland, College Park
Publications - 177
Citations - 8043
Xiaoming He is an academic researcher from University of Maryland, College Park. The author has contributed to research in topics: Cancer & Vitrification. The author has an hindex of 46, co-authored 163 publications receiving 6341 citations. Previous affiliations of Xiaoming He include University of Maryland, Baltimore & Beijing City University.
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Journal ArticleDOI
CS1-specific chimeric antigen receptor (CAR)-engineered natural killer cells enhance in vitro and in vivo antitumor activity against human multiple myeloma
Jianhong Chu,Youcai Deng,Don M. Benson,Shun He,Tiffany Hughes,Jianying Zhang,Yong Peng,Hsiaoyin Mao,Ling Yi,Kalpana Ghoshal,Xiaoming He,Steven M. Devine,Xiaoliu Zhang,Michael A. Caligiuri,Craig C. Hofmeister,Jianhua Yu +15 more
TL;DR: CS1 represents a viable target for CAR-expressing immune cells, and autologous or allogeneic transplantation of CS1-specific CAR NK cells may be a promising strategy to treat MM.
Journal ArticleDOI
Thermal stability of proteins.
John C. Bischof,Xiaoming He +1 more
TL;DR: An overview of protein stability in terms of denaturation due to temperature alteration and its modification by use of chemical additives, pH modification as well as modification of the mechanical environment (stress) of the proteins such as collagen is presented.
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CAR-Engineered NK Cells Targeting Wild-Type EGFR and EGFRvIII Enhance Killing of Glioblastoma and Patient-Derived Glioblastoma Stem Cells.
Jianfeng Han,Jianhong Chu,Wing Keung Chan,Jianying Zhang,Youwei Wang,Justus B. Cohen,Aaron R. Victor,Walter Hans Meisen,Sung Hak Kim,Paola Grandi,Qi-En Wang,Xiaoming He,Ichiro Nakano,E. Antonio Chiocca,Joseph C. Glorioso,Balveen Kaur,Michael A. Caligiuri,Jianhua Yu +17 more
TL;DR: In two orthotopic GB xenograft mouse models, intracranial administration of NK-92-EGFR-CAR cells resulted in efficient suppression of tumor growth and significantly prolonged the tumor-bearing mice survival.
Journal ArticleDOI
Targeted production of reactive oxygen species in mitochondria to overcome cancer drug resistance.
Hai Wang,Zan Gao,Xuanyou Liu,Pranay Agarwal,Shuting Zhao,Daniel W. Conroy,Guang Ji,Jianhua Yu,Christopher P. Jaroniec,Zhenguo Liu,Xiongbin Lu,Xiaodong Li,Xiaoming He +12 more
TL;DR: A mitochondria-targeting nanoparticle system that inhibits adenosine triphosphate transporter activity via reactive oxygen species generation and can thus be used to target multidrug-resistant cancer is developed.
Journal ArticleDOI
Chitosan-Decorated Doxorubicin-Encapsulated Nanoparticle Targets and Eliminates Tumor Reinitiating Cancer Stem-like Cells
Wei Rao,Hai Wang,Jianfeng Han,Shuting Zhao,Jenna Dumbleton,Pranay Agarwal,Wujie Zhang,Gang Zhao,Jianhua Yu,Debra L. Zynger,Xiongbin Lu,Xiaoming He +11 more
TL;DR: The development of nanoparticle system to target cancer stem-like cells with low systemic toxicity provides a new treatment arsenal for improving the survival of cancer patients.