抗原变异可使得多种致病微生物易于逃避宿主免疫应答。表达在感染红细胞表面的恶性疟原虫红细胞表面蛋白1（PfPMP1）与感染红细胞、内皮细胞、树突状细胞以及胎盘的单个或多个受体作用，在黏附及免疫逃避中起关键的作用。每个单倍体基因组var基因家族编码约60种成员，通过启动转录不同的var基因变异体为抗原变异提供了分子基础。

疟原虫var基因转换速率变化导致抗原变异[英]／Paul H, Robert P, Christodoulou Z, et al//Proc Natl Acad Sci U S A

We will review some of the major results in random graphs and some of the more challenging open problems. We will cover algorithmic and structural questions. We will touch on newer models, including those related to the WWW.

Random graphs

/pdf/convex-analysisnoer-san-nojin-zhan-nituite-5dl2rbmoyr.pdf

Convex Analysisの二,三の進展について

Convergence of Probability Measures. By P. Billingsley. Chichester, Sussex, Wiley, 1968. xii, 253 p. 9 1/4“. 117s.

Convergence of Probability Measures

admission. This proportion could already be greater in some parts of the country and may increase if referrals of cases of self-poisoning increase faster than the facilities for their assessment and management. The provision of social work and psychiatric expertise in casualty departments may be one means of preventing unnecessary medical admissions without risk to the patients. Dr Blake's and Dr Bramble's figures do not demonstrate, however, that any advantage would attach to medical teams taking over assessment from psychiatrists except that, by implication, assessments would be completed sooner by staff working on the ward full time. What the figures actually suggest is that if assessment of overdoses were left to house doctors there would be an increase in admissions to psychiatric units (by 19°U), outpatients (by 5O°'), and referrals to social services (by 140o). So for house doctors to assess overdoses would provide no economy for the psychiatric or social services. The study does not tell us what the consequences would have been for the six patients who the psychiatrists would have admitted but to whom the house doctors would have offered outpatient appointments. E J SALTER

Vitamin D deficiency.

We demonstrate the piezoelectric effect on the responsivity of a metalsemiconductormetal ZnO micro-/nanowire photodetector. The responsivity of the photodetector is respectively enhanced by 530%, 190%, 9%, and 15% upon 4.1 pW, 120.0 pW, 4.1 nW, and 180.4 nW UV light illumination onto the wire by introducing a0.36% compressive strain in the wire, which effectively tuned the Schottky barrier height at the contact by the produced local piezopotential. After a systematic study on the Schottky barrier height change with tuning of the strain and the excitation light intensity, an in-depth understanding is provided about the physical mechanism of the coupling of piezoelectric, optical, and semiconducting properties. Our results show that the piezo-phototronic effect can enhance the detection sensitivity more than 5-fold for pW levels of light detection.

http://xugroup.eng.ucsd.edu/wp-content/uploads/2015/09/18_acs_nano.pdf

Enhancing sensitivity of a single ZnO micro-/nanowire photodetector by piezo-phototronic effect

Owing to their atomic layer thickness, strong light–material interaction, high nonlinearity, broadband optical response, fast relaxation, controllable optoelectronic properties, and high compatibility with other photonic structures, 2D materials, including graphene, transition metal dichalcogenides and black phosphorus, have been attracting increasing attention for photonic applications. By tuning the carrier density via electrical or optical means that modifies their physical properties (e.g., Fermi level or nonlinear absorption), optical response of the 2D materials can be instantly changed, making them versatile nanostructures for optical modulation. Here, up-to-date 2D material-based optical modulation in three categories is reviewed: free-space, fiber-based, and on-chip configurations. By analysing cons and pros of different modulation approaches from material and mechanism aspects, the challenges faced by using these materials for device applications are presented. In addition, thermal effects (e.g., laser induced damage) in 2D materials, which are critical to practical applications, are also discussed. Finally, the outlook for future opportunities of these 2D materials for optical modulation is given.

2D Materials for Optical Modulation: Challenges and Opportunities.

Background—Macrophage activation plays a crucial role in regulating adipose tissue inflammation and is a major contributor to the pathogenesis of obesity-associated cardiovascular diseases. On various types of stimuli, macrophages respond with either classic (M1) or alternative (M2) activation. M1- and M2-mediated signaling pathways and corresponding cytokine production profiles are not completely understood. The discovery of microRNAs provides a new opportunity to understand this complicated but crucial network for macrophage activation and adipose tissue function. Methods and Results—We have examined the activity of microRNA-223 (miR-223) and its role in controlling macrophage functions in adipose tissue inflammation and systemic insulin resistance. miR-223−/− mice on a high-fat diet exhibited an increased severity of systemic insulin resistance compared with wild-type mice that was accompanied by a marked increase in adipose tissue inflammation. The specific regulatory effects of miR-223 in myeloid cel...

A novel regulator of macrophage activation: miR-223 in obesity-associated adipose tissue inflammation.

We report direct coupling of plasmonic and photonic nanowires using ultracompact near-field interaction. Photon-plasmon coupling efficiency up to 80% with coupling length down to the 200 nm level is achieved between individual Ag and ZnO nanowires. Hybrid nanophotonic components, including polarization splitters, Mach-Zehnder interferometers, and microring cavities, are fabricated out of coupled Ag and ZnO nanowires. These components offer relatively low loss with subwavelength confinement; a hybrid nanowire microcavity exhibits a Q-factor of 520.

/pdf/direct-coupling-of-plasmonic-and-photonic-nanowires-for-422izcsk66.pdf

Direct coupling of plasmonic and photonic nanowires for hybrid nanophotonic components and circuits.

We consider the problem of predicting a random variable X from observations, denoted by a random variable Z. It is well known that the conditional expectation E[X|Z] is the optimal L/sup 2/ predictor (also known as "the least-mean-square error" predictor) of X, among all (Borel measurable) functions of Z. In this orrespondence, we provide necessary and sufficient conditions for the general loss functions under which the conditional expectation is the unique optimal predictor. We show that E[X|Z] is the optimal predictor for all Bregman loss functions (BLFs), of which the L/sup 2/ loss function is a special case. Moreover, under mild conditions, we show that the BLFs are exhaustive, i.e., if for every random variable X, the infimum of E[F(X,y)] over all constants y is attained by the expectation E[X], then F is a BLF.

/pdf/on-the-optimality-of-conditional-expectation-as-a-bregman-4j7eau4r97.pdf

Xin Guo

Papers

Enhancing sensitivity of a single ZnO micro-/nanowire photodetector by piezo-phototronic effect

2D Materials for Optical Modulation: Challenges and Opportunities.

A novel regulator of macrophage activation: miR-223 in obesity-associated adipose tissue inflammation.

Direct coupling of plasmonic and photonic nanowires for hybrid nanophotonic components and circuits.

On the optimality of conditional expectation as a Bregman predictor