Xin Yu

TL;DR: The data suggest that TIGIT exerts immunosuppressive effects by binding to poliovirus receptor and modulating cytokine production by dendritic cells.

TL;DR: A key role is defined for TIGIT in inhibiting chronic CD8(+) T cell-dependent responses to tumor formation and chronic immune responses to chronic viral infection.

TL;DR: An integrated RNA-sequencing approach demonstrates that CXCL13+ TH1-like cells are preferentially enriched in microsatellite-instable tumours from patients with colorectal cancer, and IGFLR1 is identified as a co-stimulatory molecule.

TL;DR: This comprehensive analysis of key myeloid subsets in human and mouse identifies critical cellular interactions regulating tumor immunity and defines mechanisms underlying myeloids-targeted immunotherapies currently undergoing clinical testing.

TL;DR: The results show that the BRCT domains interact in vivo with CtIP, a protein originally identified on the basis of its association with the CtBP transcriptional co-repressor, suggesting that BRCA1 regulates gene expression, at least in part, by modulating CtBP-mediated transcriptional repression.