L
Lei Zhang
Researcher at Peking University
Publications - 24
Citations - 3149
Lei Zhang is an academic researcher from Peking University. The author has contributed to research in topics: Cancer & Cell. The author has an hindex of 13, co-authored 23 publications receiving 1410 citations. Previous affiliations of Lei Zhang include Centre for Life.
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Journal ArticleDOI
Global characterization of T cells in non-small-cell lung cancer by single-cell sequencing.
Guo Xinyi,Yuanyuan Zhang,Liangtao Zheng,Chunhong Zheng,Jintao Song,Qiming Zhang,Boxi Kang,Zhouzerui Liu,Liang Jin,Rui Xing,Ranran Gao,Lei Zhang,Minghui Dong,Xueda Hu,Xianwen Ren,Dennis Kirchhoff,Helge Roider,Tiansheng Yan,Zemin Zhang +18 more
TL;DR: Deep single-cell RNA sequencing of tumor-infiltrating T cells in non-small-cell lung cancer identifies features associated with functional states and clinical outcome and provides a new approach for patient stratification.
Journal ArticleDOI
Lineage tracking reveals dynamic relationships of T cells in colorectal cancer.
Lei Zhang,Xin Yu,Liangtao Zheng,Yuanyuan Zhang,Yansen Li,Qiao Fang,Ranran Gao,Boxi Kang,Qiming Zhang,Julie Y. Huang,Hiroyasu Konno,Guo Xinyi,Yingjiang Ye,Songyuan Gao,Shan Wang,Xueda Hu,Xianwen Ren,Zhanlong Shen,Wenjun Ouyang,Zemin Zhang +19 more
TL;DR: An integrated RNA-sequencing approach demonstrates that CXCL13+ TH1-like cells are preferentially enriched in microsatellite-instable tumours from patients with colorectal cancer, and IGFLR1 is identified as a co-stimulatory molecule.
Journal ArticleDOI
Single-Cell Analyses Inform Mechanisms of Myeloid-Targeted Therapies in Colon Cancer.
Lei Zhang,Ziyi Li,Katarzyna M. Skrzypczynska,Qiao Fang,Wei Zhang,Sarah A. O’Brien,Yao He,Lynn Wang,Qiming Zhang,Aeryon Kim,Ranran Gao,Jessica Orf,Tao Wang,Deepali V. Sawant,Jiajinlong Kang,Dev Bhatt,Daniel Lu,Chi-Ming Li,Aaron S. Rapaport,Kristy Perez,Yingjiang Ye,Shan Wang,Xueda Hu,Xianwen Ren,Wenjun Ouyang,Zhanlong Shen,Jackson G. Egen,Zemin Zhang,Xin Yu +28 more
TL;DR: This comprehensive analysis of key myeloid subsets in human and mouse identifies critical cellular interactions regulating tumor immunity and defines mechanisms underlying myeloids-targeted immunotherapies currently undergoing clinical testing.
Journal ArticleDOI
A pan-cancer single-cell transcriptional atlas of tumor infiltrating myeloid cells.
Sijin Cheng,Ziyi Li,Ranran Gao,Baocai Xing,Yunong Gao,Yu Yang,Shishang Qin,Lei Zhang,Hanqiang Ouyang,Peng Du,Liang Jiang,Bin Zhang,Yue Yang,Xiliang Wang,Xianwen Ren,Jin-Xin Bei,Xueda Hu,Zhaode Bu,Jiafu Ji,Zemin Zhang +19 more
TL;DR: A pan-cancer analysis of single myeloid cells from 210 patients across 15 human cancer types identified distinct features of TIMs across cancer types and suggested future avenues for rational, targeted immunotherapies.
Journal ArticleDOI
A circulating miRNA signature as a diagnostic biomarker for non-invasive early detection of breast cancer
Lei Zhang,Ye Xu,Xingyu Jin,Zengwu Wang,Yidi Wu,Deyao Zhao,Gang Chen,Deyu Li,Xiaoxia Wang,Huiqing Cao,Yuntao Xie,Zicai Liang +11 more
TL;DR: The data demonstrate that the SdM-RT-PCR assay is an effective breast cancer profiling method that utilizes very small volumes and is compatible with Biobank and the identified 3-miRNA signature is a promising circulating biomarker for breast cancer diagnosis.