Showing papers in "Chemico-Biological Interactions in 2018"

TL;DR: An overview of the molecular mechanisms of TGF-β/Smad signaling pathway in renal, hepatic, pulmonary and cardiac fibrosis is presented and particular challenges are presented and placed within the context of future applications against tissue fibrosis.

TL;DR: Different nanoparticle attachment to gram + and gram - bacterial surface and different mechanism adopted by nanoparticle for bacterial control are highlighted.

TL;DR: Understanding of the molecular pathways and their interaction might be advantageous in the development of novel therapeutic approaches for rheumatoid arthritis.

TL;DR: The highlighting of limonene applications could develop a useful targeting of innovative research in this field as well as the development of a limonenes-based phytomedicine which could be used in a variety of conditions of health and disease.

TL;DR: Red blood cells (RBCs) plasma membrane is a multi-component structure that keeps the cell morphology, elasticity, flexibility and deformability, which makes RBCs a valuable in vitro model to evaluate the cytotoxicity of different natural or synthetic and organic or inorganic molecules by cellular damage measures.

TL;DR: The data suggested that Iso protected against oxidative stress and neuronal apoptosis in in vivo and in vitro cerebral I/R injury models via Nrf2-mediated inhibition of the NOX4/ROS/NF-κB signaling pathway.

TL;DR: Metal and metal oxide NPs in dermatology and cosmetology and their interactions with skin cells are reviewed, which shows very promising clinical potential to serve as controlled release and delivery systems for drugs/active substances.

TL;DR: The results corroborated with the neuroprotective effect of chrysin in the treatment of Parkinson's disease and indicated the mechanism involved throught the inflammatory cytokines, neurotrophic factors and recovery of dopaminergic neurons in striatum.

TL;DR: This review summarizes the knowledge on nanoparticles, including their various applications, routes of exposure, their potential toxicity and risks to human health.

TL;DR: Vitamin C appeared to be the superior antioxidant out of the traditional antioxidants; and compound 4 was superior to other tested thiazolidinone derivatives.

TL;DR: It is shown that the naringin-enhanced EPC proliferation and tube formation were mediated by the activation of the PI3K/Akt signaling pathway via the CXCL12/CXCR4 axis, which suggests that naring in could serve as a new therapeutic medicine and has the potential to be applied for the treatment of ischemic disease.

TL;DR: Crocin's ameliorative impact on diabetes mellitus may be attributed to its free radicals scavenging properties, its ability to enhance host antioxidant defense system and its able to inhibit inflammatory and fibrotic cascades activation.

TL;DR: In vivo studies applying different models of induced ischemia and reperfusion (I/R) injury confirm astaxanthin's protective action after oral or intravenous administration, but some studies have shown some limitations after oral administration such as low stability, bioavailability and bioefficacy, revealing a need for the implementation of new biomaterials to act as astrixanthin vehicles in vivo.

TL;DR: In this paper, the authors investigated the use of multifunctional nanoparticles that designed with a Nano-graphene oxide (NGO) sheet functionalized with magnetic poly (lactic-co-glycolic acid) (PLGA) and was used for glioma targeting delivery of radiosensitizing 5-iodo-2-deoxyuridine (IUdR).

TL;DR: The present results emphasize that a test battery approach of bioassays representing multiple trophic levels is fundamental in predicting the toxicity of textile dyes, aside from providing the information required to define their safe levels for living organisms in the environment.

TL;DR: It is suggested that VDAC-mediated Ca 2+ influx into mitochondria and subsequent mitochondrial Ca2+ overload contribute to mitochondrial swelling and dysfunction, leading to morusin-induced paraptosis-like cell death in EOC.

TL;DR: These findings provide the first demonstration of the anticancer effect of TQ on bladder cancer, and the relationship between ER stress and mitochondrial dysfunction was clearly understood when the apoptosis progressed is revealed.

TL;DR: Evidence is provided that apigenin sensitizes BEL-7402/ADM cells to doxorubicin through miR-520b/ATG7 pathway, which furtherly supports apigen in as a potential chemo-sensitizer for hepatocellular carcinoma.

TL;DR: SA1 and SA2 might be potential antidiabetic lead compounds for future drug development after it was suggested that both compounds reduced blood glucose level, restored body weight, and normalized lipid concentrations in the serum and oxidative stress biomarkers in the liver and pancreas.

TL;DR: Mechanistic insights revealed that p-CA inhibits Grp78 upregulation in cancer cells through activation of PERK-eIF2α-ATF-4-CHOP pathway that culminates in apoptosis inducing effect of p- CA.

TL;DR: Light is shed on nifuroxazide's efficacy as an alternative anti-inflammatory therapy to hinder the development and progression of DN in diabetic patients mainly via STAT3 inhibition.

TL;DR: A new generation of the more effective polymeric micelle and nanoparticle drug delivery systems evolved due to the emergence of stimuli-responsive polymers that can be very efficient due to their ability to wisely distinguish between pathological and healthy tissues.

TL;DR: BBR is a potential therapeutic candidate for liver fibrosis owing to its antioxidant and anti-inflammatory activities and shows an increase in the expression of apoptotic markers.

TL;DR: GSTs play major role in the detoxification of reactive metabolites of methylcholanthrene by mediating catalytic binding with GSH to form a highly soluble detoxified complex which is then eliminated.

TL;DR: Optimal conditions facilitated the complete degradation of the dye without [H2O2residual] or toxicity for samples treated with the Fenton-like process, whereas the Fentin process induced significant mortality for A. salina.

TL;DR: The review showed that Hcy levels range in uncomplicated pregnancy and that, Hcy level tends to decrease during the second and third trimesters, andufficient data were obtained indicating the relationship between HHcy and PE.

TL;DR: Thymoquinone nanocapsules (actually containing half of the doses of thymoquone) produced better antihyperglycemic effect in type-2 diabetic rats as compared to thymOquinone alone.

TL;DR: This work is an attempt to make the readers understand the positive implications of these compounds and indicates the significant developments of utilizing cannabinoids as therapeutic agents.

TL;DR: Phospholipophilicity shows the highest correlation to cellular accumulation data in both cell types and best distinguishes between high and low accumulating compounds, indicating that binding to phospholipids may be the most important component in driving high cellular accumulation in lung epithelial cells, as well as in adipocytes, and for both CADs and bioaccumulating PFASs.

TL;DR: It is demonstrated that NKILA enhances the anti-cancer effects of baicalein on HCC in vitro and in vivo via the regulation of NF-κB signaling, and implied that the combination of NKILA and baicalsein would be potential therapeutic strategies for HCC.