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Xu Tan
Researcher at Tsinghua University
Publications - 43
Citations - 4007
Xu Tan is an academic researcher from Tsinghua University. The author has contributed to research in topics: Medicine & Biology. The author has an hindex of 17, co-authored 31 publications receiving 3333 citations. Previous affiliations of Xu Tan include Center for Infectious Disease Research and Policy & National Center for Electron Microscopy.
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Journal ArticleDOI
Mechanism of auxin perception by the TIR1 ubiquitin ligase
Xu Tan,Luz Irina A. Calderon-Villalobos,Michal Sharon,Changxue Zheng,Carol V. Robinson,Mark Estelle,Ning Zheng +6 more
TL;DR: These structures show that the leucine-rich repeat domain of TIR1 contains an unexpected inositol hexakisphosphate co-factor and recognizes auxin and the Aux/IAA polypeptide substrate through a single surface pocket, establishing the first structural model of a plant hormone receptor.
Journal ArticleDOI
A chromatin localization screen reveals poly (ADP ribose)-regulated recruitment of the repressive polycomb and NuRD complexes to sites of DNA damage
Danny M. Chou,Brittany Susan Adamson,Noah Dephoure,Xu Tan,Amanda C. Nottke,Kristen E. Hurov,Steven P. Gygi,Monica P. Colaiácovo,Stephen J. Elledge +8 more
TL;DR: It is proposed that PARP sets up a transient repressive chromatin structure at sites of DNA damage to block transcription and facilitate DNA repair.
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A combinatorial TIR1/AFB–Aux/IAA co-receptor system for differential sensing of auxin
Luz Irina A. Calderón Villalobos,Sarah Lee,César Augusto F. de Oliveira,Anthony Ivetac,Wolfgang Brandt,Lynne Armitage,Laura B. Sheard,Xu Tan,Xu Tan,Geraint Parry,Geraint Parry,Haibin Mao,Ning Zheng,Richard M. Napier,Stefan Kepinski,Mark Estelle +15 more
TL;DR: It is demonstrated that the AFB5-Aux/IAA co-receptor selectively binds the auxinic herbicide picloram, which broadens the effective concentration range of the hormone and may contribute to the complexity of auxin response.
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A non-viral CRISPR/Cas9 delivery system for therapeutically targeting HBV DNA and pcsk9 in vivo
Chao Jiang,Miao Mei,Bin Li,Xiurui Zhu,Wenhong Zu,Yujie Tian,Qiannan Wang,Yong Guo,Yizhou Dong,Xu Tan +9 more
TL;DR: A non-viral CRISPR/Cas9 delivery system for therapeutically targeting HBV DNA and pcsk9 in vivo and its application in vivo is described.
Journal ArticleDOI
Small-molecule agonists and antagonists of F-box protein–substrate interactions in auxin perception and signaling
Ken-ichiro Hayashi,Xu Tan,Ning Zheng,Tatsuya Hatate,Yoshio Kimura,Stefan Kepinski,Hiroshi Nozaki +6 more
TL;DR: The design, synthesis, and characterization of a series of auxin agonists and antagonists are described, which support the idea that it may be possible to design small-molecule agents to modulate ubiquitin-ligase function therapeutically and demonstrate an example of a specific small- molecule inhibitor of F-box protein–substrate recruitment.